Branch formation during organ development

Nikolce Gjorevski, Celeste M. Nelson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Invertebrates and vertebrates use branching morphogenesis to build epithelial trees to maximize the surface area of organs within a given volume. Several molecular regulators of branching have recently been discovered, a number of which are conserved across different organs and species. Signals that control branching at the cellular and tissue levels are also starting to emerge, and are rapidly unveiling the physical nature of branch development. Here we discuss the molecular, cellular, and physical processes that govern branch formation, and highlight the major outstanding questions in the field.

Original languageEnglish (US)
Pages (from-to)734-741
Number of pages8
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Issue number6
StatePublished - Nov 2010

All Science Journal Classification (ASJC) codes

  • General Medicine


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