Boron binding with the quorum sensing signal Al-2 and analogues

Martin F. Semmelhack; Shawn R. Campagna; Charlotte Hwa; Michael J. Federle; Bonnie L. Bassler

doi:10.1021/ol048976u

Boron binding with the quorum sensing signal Al-2 and analogues

Martin F. Semmelhack, Shawn R. Campagna, Charlotte Hwa, Michael J. Federle, Bonnie L. Bassler

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

(Matrix Presented) The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi Al-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying V. harveyi Al-2 from the biosynthetic product.

Original language	English (US)
Pages (from-to)	2635-2637
Number of pages	3
Journal	Organic letters
Volume	6
Issue number	15
DOIs	https://doi.org/10.1021/ol048976u
State	Published - Jul 22 2004

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol048976u

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abstract = "(Matrix Presented) The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi Al-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying V. harveyi Al-2 from the biosynthetic product.",

author = "Semmelhack, \{Martin F.\} and Campagna, \{Shawn R.\} and Charlotte Hwa and Federle, \{Michael J.\} and Bassler, \{Bonnie L.\}",

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doi = "10.1021/ol048976u",

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journal = "Organic letters",

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T1 - Boron binding with the quorum sensing signal Al-2 and analogues

AU - Semmelhack, Martin F.

AU - Campagna, Shawn R.

AU - Hwa, Charlotte

AU - Federle, Michael J.

AU - Bassler, Bonnie L.

PY - 2004/7/22

Y1 - 2004/7/22

N2 - (Matrix Presented) The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi Al-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying V. harveyi Al-2 from the biosynthetic product.

AB - (Matrix Presented) The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi Al-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying V. harveyi Al-2 from the biosynthetic product.

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JO - Organic letters

JF - Organic letters

IS - 15

ER -

Boron binding with the quorum sensing signal Al-2 and analogues

Abstract

All Science Journal Classification (ASJC) codes

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