Boron binding with the quorum sensing signal Al-2 and analogues

Martin F. Semmelhack; Shawn R. Campagna; Charlotte Hwa; Michael J. Federle; Bonnie L. Bassler

doi:10.1021/ol048976u

Boron binding with the quorum sensing signal Al-2 and analogues

Martin F. Semmelhack, Shawn R. Campagna, Charlotte Hwa, Michael J. Federle, Bonnie L. Bassler

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

(Matrix Presented) The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi Al-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying V. harveyi Al-2 from the biosynthetic product.

Original language	English (US)
Pages (from-to)	2635-2637
Number of pages	3
Journal	Organic letters
Volume	6
Issue number	15
DOIs	https://doi.org/10.1021/ol048976u
State	Published - Jul 22 2004

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol048976u

Cite this

@article{863fa6ff34084d519504f5ef210c1d33,

title = "Boron binding with the quorum sensing signal Al-2 and analogues",

abstract = "(Matrix Presented) The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi Al-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying V. harveyi Al-2 from the biosynthetic product.",

author = "Semmelhack, {Martin F.} and Campagna, {Shawn R.} and Charlotte Hwa and Federle, {Michael J.} and Bassler, {Bonnie L.}",

year = "2004",

month = jul,

day = "22",

doi = "10.1021/ol048976u",

language = "English (US)",

volume = "6",

pages = "2635--2637",

journal = "Organic letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "15",

}

TY - JOUR

T1 - Boron binding with the quorum sensing signal Al-2 and analogues

AU - Semmelhack, Martin F.

AU - Campagna, Shawn R.

AU - Hwa, Charlotte

AU - Federle, Michael J.

AU - Bassler, Bonnie L.

PY - 2004/7/22

Y1 - 2004/7/22

N2 - (Matrix Presented) The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi Al-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying V. harveyi Al-2 from the biosynthetic product.

AB - (Matrix Presented) The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi Al-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying V. harveyi Al-2 from the biosynthetic product.

UR - http://www.scopus.com/inward/record.url?scp=4043080762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4043080762&partnerID=8YFLogxK

U2 - 10.1021/ol048976u

DO - 10.1021/ol048976u

M3 - Article

C2 - 15255709

AN - SCOPUS:4043080762

SN - 1523-7060

VL - 6

SP - 2635

EP - 2637

JO - Organic letters

JF - Organic letters

IS - 15

ER -

Boron binding with the quorum sensing signal Al-2 and analogues

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this