Boron binding with the quorum sensing signal Al-2 and analogues

Martin F. Semmelhack, Shawn R. Campagna, Charlotte Hwa, Michael J. Federle, Bonnie L. Bassler

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


(Matrix Presented) The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analogue. The boron complex of DPD is Vibrio harveyi Al-2, an interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying V. harveyi Al-2 from the biosynthetic product.

Original languageEnglish (US)
Pages (from-to)2635-2637
Number of pages3
JournalOrganic letters
Issue number15
StatePublished - Jul 22 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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