@article{ba0525d916ca4c7ca2e89b90488f0870,
title = "Bone vascular niche E-selectin induces mesenchymal–epithelial transition and Wnt activation in cancer cells to promote bone metastasis",
abstract = "How disseminated tumour cells engage specific stromal components in distant organs for survival and outgrowth is a critical but poorly understood step of the metastatic cascade. Previous studies have demonstrated the importance of the epithelial–mesenchymal transition in promoting the cancer stem cell properties needed for metastasis initiation, whereas the reverse process of mesenchymal–epithelial transition is required for metastatic outgrowth. Here we report that this paradoxical requirement for the simultaneous induction of both mesenchymal–epithelial transition and cancer stem cell traits in disseminated tumour cells is provided by bone vascular niche E-selectin, whose direct binding to cancer cells promotes bone metastasis by inducing mesenchymal–epithelial transition and activating Wnt signalling. E-selectin binding activity mediated by the α1-3 fucosyltransferases Fut3/Fut6 and Glg1 are instrumental to the formation of bone metastasis. These findings provide unique insights into the functional role of E-selectin as a component of the vascular niche critical for metastatic colonization in bone.",
author = "Mark Esposito and Nandini Mondal and Greco, {Todd M.} and Yong Wei and Chiara Spadazzi and Lin, {Song Chang} and Hanqiu Zheng and Corey Cheung and Magnani, {John L.} and Lin, {Sue Hwa} and Cristea, {Ileana M.} and Robert Sackstein and Yibin Kang",
note = "Funding Information: We thank L. M. Wakefield for providing the SORE6–mCherry stemness reporter, R. Nusse for providing the 7×TCF–GFP Wnt reporter, G. Laevsky for assistance with microscopy and C. DeCoste for assistance with flow cytometry. This work was supported by fellowships from the NIH (grant no. F31CA192461) and NJCCR to M.E., the National Institutes of Health NHLBI (grant no. PO1 HL107146), the Program of Excellence in Glycosciences and the Team Jobie Fund to R.S., and grants from the Susan G. Komen Foundation (grant no. SAC160067), Glycomimetics Inc., Brewster Foundation, Department of Defense (grant no. BC123187) and the National Institutes of Health (grant no. R01CA141062) to Y.K. This research was also supported by the Preclinical Imaging, Genomic Editing and Flow Cytometry Shared Resources of the Rutgers Cancer Institute of New Jersey (grant no. P30CA072720). Publisher Copyright: {\textcopyright} 2019, The Author(s), under exclusive licence to Springer Nature Limited.",
year = "2019",
month = may,
day = "1",
doi = "10.1038/s41556-019-0309-2",
language = "English (US)",
volume = "21",
pages = "627--639",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "5",
}