Abstract
Metastasis to bone is determined by both inherent characteristics of tumor cells and properties of bone niches. The bone-residing cells and bone-derived factors not only participate in maintaining dynamic bone homeostasis but also form specific niches, including premetastatic niche, perivascular niches, and stem cell niche for the seeding, survival, and outgrowth of disseminated tumor cells in bone. The main components in bone tissue that contribute to bone metastasis include hematopoietic stem cell (HSC)-osteoclast cell lineage, mesenchymal stem cell (MSC)-osteoblast cell lineage, and extracellular matrix and immune cells in bone marrow. Understanding of the complicated and dynamic nature of bone tissue and cancer cell-bone niche interactions may shed light into the mystery of metastatic dormancy, outgrowth, and progression, and facilitate the development of novel preventive or therapeutic strategies for bone metastasis.
| Original language | English (US) |
|---|---|
| Title of host publication | Bone Cancer |
| Subtitle of host publication | Bone Sarcomas and Bone Metastases - From Bench to Bedside |
| Publisher | Elsevier |
| Pages | 107-119 |
| Number of pages | 13 |
| ISBN (Electronic) | 9780128216668 |
| DOIs | |
| State | Published - Jan 1 2021 |
All Science Journal Classification (ASJC) codes
- General Medicine
Keywords
- Bone metastasis
- Cancer therapy
- Disseminated tumor cells
- Dormancy
- Metastatic niche
- Osteoblasts
- Osteoclasts
- Tumor microenvironment