Bone marrow niches in the regulation of bone metastasis

Fenfang Chen, Yujiao Han, Yibin Kang

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

The bone marrow has been widely recognised to host a unique microenvironment that facilitates tumour colonisation. Bone metastasis frequently occurs in the late stages of malignant diseases such as breast, prostate and lung cancers. The biology of bone metastasis is determined by tumour-cell-intrinsic traits as well as their interaction with the microenvironment. The bone marrow is a dynamic organ in which various stages of haematopoiesis, osteogenesis, osteolysis and different kinds of immune response are precisely regulated. These different cellular components constitute specialised tissue microenvironments—niches—that play critical roles in controlling tumour cell colonisation, including initial seeding, dormancy and outgrowth. In this review, we will dissect the dynamic nature of the interactions between tumour cells and bone niches. By targeting certain steps of tumour progression and crosstalk with the bone niches, the development of potential therapeutic approaches for the clinical treatment of bone metastasis might be feasible.

Original languageEnglish (US)
Pages (from-to)1912-1920
Number of pages9
JournalBritish Journal of Cancer
Volume124
Issue number12
DOIs
StatePublished - Jun 8 2021

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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