Bonding organics to Ti alloys: Facilitating human osteoblast attachment and spreading on surgical implant materials

The surface coverage and subsequent arginine-glycine-aspartic acid (RGD) derivatization of the Ti-6Al-4V surface which can be readily effected by silanization in amounts far higher on a surface-bound Ti phosphate interface that can be accomplished on the native oxide by standard methods were shown. Nonetheless, the inherent hydrolytic instability under physiological conditions of surface siloxanes ultimately limits their utility. Thus, a successful surface chemistry approach for creating stable osteoconductive surfaces on Ti and Ti-6Al-4V was found.