Bonding organics to Ti alloys: Facilitating human osteoblast attachment and spreading on surgical implant materials

Ellen S. Gawalt, Michael J. Avaltroni, Michael P. Danahy, Brett M. Silverman, Eric L. Hanson, Kim S. Midwood, Jean E. Schwarzbauer, Jeffrey Schwartz

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

The surface coverage and subsequent arginine-glycine-aspartic acid (RGD) derivatization of the Ti-6Al-4V surface which can be readily effected by silanization in amounts far higher on a surface-bound Ti phosphate interface that can be accomplished on the native oxide by standard methods were shown. Nonetheless, the inherent hydrolytic instability under physiological conditions of surface siloxanes ultimately limits their utility. Thus, a successful surface chemistry approach for creating stable osteoconductive surfaces on Ti and Ti-6Al-4V was found.

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalLangmuir
Volume19
Issue number1
DOIs
StatePublished - Jan 7 2003

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Fingerprint Dive into the research topics of 'Bonding organics to Ti alloys: Facilitating human osteoblast attachment and spreading on surgical implant materials'. Together they form a unique fingerprint.

  • Cite this