Bonding organics to Ti alloys: Facilitating human osteoblast attachment and spreading on surgical implant materials

Ellen S. Gawalt; Michael J. Avaltroni; Michael P. Danahy; Brett M. Silverman; Eric L. Hanson; Kim S. Midwood; Jean E. Schwarzbauer; Jeffrey Schwartz

doi:10.1021/la0203436

Bonding organics to Ti alloys: Facilitating human osteoblast attachment and spreading on surgical implant materials

Ellen S. Gawalt, Michael J. Avaltroni, Michael P. Danahy, Brett M. Silverman, Eric L. Hanson, Kim S. Midwood, Jean E. Schwarzbauer, Jeffrey Schwartz

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The surface coverage and subsequent arginine-glycine-aspartic acid (RGD) derivatization of the Ti-6Al-4V surface which can be readily effected by silanization in amounts far higher on a surface-bound Ti phosphate interface that can be accomplished on the native oxide by standard methods were shown. Nonetheless, the inherent hydrolytic instability under physiological conditions of surface siloxanes ultimately limits their utility. Thus, a successful surface chemistry approach for creating stable osteoconductive surfaces on Ti and Ti-6Al-4V was found.

Original language	English (US)
Pages (from-to)	200-204
Number of pages	5
Journal	Langmuir
Volume	19
Issue number	1
DOIs	https://doi.org/10.1021/la0203436
State	Published - Jan 7 2003

All Science Journal Classification (ASJC) codes

Materials Science(all)
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la0203436

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title = "Bonding organics to Ti alloys: Facilitating human osteoblast attachment and spreading on surgical implant materials",

abstract = "The surface coverage and subsequent arginine-glycine-aspartic acid (RGD) derivatization of the Ti-6Al-4V surface which can be readily effected by silanization in amounts far higher on a surface-bound Ti phosphate interface that can be accomplished on the native oxide by standard methods were shown. Nonetheless, the inherent hydrolytic instability under physiological conditions of surface siloxanes ultimately limits their utility. Thus, a successful surface chemistry approach for creating stable osteoconductive surfaces on Ti and Ti-6Al-4V was found.",

author = "Gawalt, {Ellen S.} and Avaltroni, {Michael J.} and Danahy, {Michael P.} and Silverman, {Brett M.} and Hanson, {Eric L.} and Midwood, {Kim S.} and Schwarzbauer, {Jean E.} and Jeffrey Schwartz",

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T2 - Facilitating human osteoblast attachment and spreading on surgical implant materials

AU - Gawalt, Ellen S.

AU - Avaltroni, Michael J.

AU - Danahy, Michael P.

AU - Silverman, Brett M.

AU - Hanson, Eric L.

AU - Midwood, Kim S.

AU - Schwarzbauer, Jean E.

AU - Schwartz, Jeffrey

PY - 2003/1/7

Y1 - 2003/1/7

N2 - The surface coverage and subsequent arginine-glycine-aspartic acid (RGD) derivatization of the Ti-6Al-4V surface which can be readily effected by silanization in amounts far higher on a surface-bound Ti phosphate interface that can be accomplished on the native oxide by standard methods were shown. Nonetheless, the inherent hydrolytic instability under physiological conditions of surface siloxanes ultimately limits their utility. Thus, a successful surface chemistry approach for creating stable osteoconductive surfaces on Ti and Ti-6Al-4V was found.

AB - The surface coverage and subsequent arginine-glycine-aspartic acid (RGD) derivatization of the Ti-6Al-4V surface which can be readily effected by silanization in amounts far higher on a surface-bound Ti phosphate interface that can be accomplished on the native oxide by standard methods were shown. Nonetheless, the inherent hydrolytic instability under physiological conditions of surface siloxanes ultimately limits their utility. Thus, a successful surface chemistry approach for creating stable osteoconductive surfaces on Ti and Ti-6Al-4V was found.

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Bonding organics to Ti alloys: Facilitating human osteoblast attachment and spreading on surgical implant materials

Abstract

All Science Journal Classification (ASJC) codes

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