Bipolar cellular morphology of malignant melanoma in unstained human melanoma skin tissue

Kai Zhang, Wenkai Zhang, Chia Yi Yang, Haw Yang

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Microstructures of unstained human melanoma skin tissues have been examined by multimodal nonlinear optical microscopy. The polarized shape of the individual melanoma cell can be readily recognized - a phenotype that has been identified in laboratory cultures as characteristic of proliferating melanocytes but has not been demonstrated in clinical instances. The results thus provide snapshots of invading melanoma cells in their native environment and suggest a practical means of connecting in vitro laboratory studies to in vivo processes.

Original languageEnglish (US)
Article number024042
JournalJournal of Biomedical Optics
Volume14
Issue number2
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Keywords

  • cell-extracellular matrix interaction
  • optical microscopy
  • second harmonic generation (SHG)
  • skin cancer
  • two-photon excited fluorescence

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