Biotechnology of extremely thermophilic archaea

Christopher T. Straub, James A. Counts, DIep M.N. Nguyen, Chang Hao Wu, Benjamin M. Zeldes, James R. Crosby, Jonathan M. Conway, Jonathan K. Otten, Gina L. Lipscomb, Gerrit J. Schut, Michael W.W. Adams, Robert M. Kelly

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


Although the extremely thermophilic archaea (Topt ≥ 70°C) may be the most primitive extant forms of life, they have been studied to a limited extent relative to mesophilic microorganisms. Many of these organisms have unique biochemical and physiological characteristics with important biotechnological implications. These include methanogens that generate methane, fermentative anaerobes that produce hydrogen gas with high efficiency, and acidophiles that can mobilize base, precious and strategic metals from mineral ores. Extremely thermophilic archaea have also been a valuable source of thermoactive, thermostable biocatalysts, but their use as cellular systems has been limited because of the general lack of facile genetics tools. This situation has changed recently, however, thereby providing an important avenue for understanding their metabolic and physiological details and also opening up opportunities for metabolic engineering efforts. Along these lines, extremely thermophilic archaea have recently been engineered to produce a variety of alcohols and industrial chemicals, in some cases incorporating CO2 into the final product. There are barriers and challenges to these organisms reaching their full potential as industrial microorganisms but, if these can be overcome, a new dimension for biotechnology will be forthcoming that strategically exploits biology at high temperatures.

Original languageEnglish (US)
Pages (from-to)543-578
Number of pages36
JournalFEMS Microbiology Reviews
Issue number5
StatePublished - Sep 1 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Medicine


  • Biocatalysis
  • Biooxidation
  • Biotechnology
  • Extremely thermophilic archaea


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