Biotechnology at low Reynolds numbers

James P. Brody; Paul Yager; Raymond E. Goldstein; Robert H. Austin

doi:10.1016/S0006-3495(96)79538-3

Biotechnology at low Reynolds numbers

James P. Brody
, Paul Yager
, Raymond E. Goldstein
, Robert H. Austin

Research output: Contribution to journal › Article › peer-review

459 Scopus citations

Abstract

The shrinking of liquid handling systems to the micron and submicron size range entails moving into the area of small Reynolds numbers. The fluid dynamics in this regime are very different from the macroscale. We present an intuitive explanation of how the different physics of small Reynolds numbers flow, along with microscopic sizes, can influence device design, and give examples from our own work using fluid flow in microfabricated devices designed for biological processing.

Original language	English (US)
Pages (from-to)	3430-3441
Number of pages	12
Journal	Biophysical Journal
Volume	71
Issue number	6
DOIs	https://doi.org/10.1016/S0006-3495(96)79538-3
State	Published - Dec 1996

All Science Journal Classification (ASJC) codes

Biophysics

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10.1016/S0006-3495(96)79538-3

Cite this

@article{92c965a7a6ce4018bc0785b96ba6419a,

title = "Biotechnology at low Reynolds numbers",

abstract = "The shrinking of liquid handling systems to the micron and submicron size range entails moving into the area of small Reynolds numbers. The fluid dynamics in this regime are very different from the macroscale. We present an intuitive explanation of how the different physics of small Reynolds numbers flow, along with microscopic sizes, can influence device design, and give examples from our own work using fluid flow in microfabricated devices designed for biological processing.",

author = "Brody, \{James P.\} and Paul Yager and Goldstein, \{Raymond E.\} and Austin, \{Robert H.\}",

note = "Funding Information: discussions. Acquisition and analysis of the rectangular flow velocity and hydrodynamic focusing profiles was done by Amulya Vamsi Madhav at Princeton. Microfabrication work was done both at the Washington Tech-nology Center and the Cornell Nanofabrication Facility. J. P. B. and P. Y. were supported by DARPA (through grant \#DAMD17-94-J-4460), Senmed Medical Ventures, and the Washington Technology Center. R. E. G. was supported by NSF PFF Grant DMR93-50227 and the A. P. Sloan Foundation. R. H. A. was supported by a grant from the Office of Naval Research and unpaid bills at the Cornell Nanofabrication Facility.",

year = "1996",

month = dec,

doi = "10.1016/S0006-3495(96)79538-3",

language = "English (US)",

volume = "71",

pages = "3430--3441",

journal = "Biophysical Journal",

issn = "0006-3495",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Biotechnology at low Reynolds numbers

AU - Brody, James P.

AU - Yager, Paul

AU - Goldstein, Raymond E.

AU - Austin, Robert H.

N1 - Funding Information: discussions. Acquisition and analysis of the rectangular flow velocity and hydrodynamic focusing profiles was done by Amulya Vamsi Madhav at Princeton. Microfabrication work was done both at the Washington Tech-nology Center and the Cornell Nanofabrication Facility. J. P. B. and P. Y. were supported by DARPA (through grant #DAMD17-94-J-4460), Senmed Medical Ventures, and the Washington Technology Center. R. E. G. was supported by NSF PFF Grant DMR93-50227 and the A. P. Sloan Foundation. R. H. A. was supported by a grant from the Office of Naval Research and unpaid bills at the Cornell Nanofabrication Facility.

PY - 1996/12

Y1 - 1996/12

N2 - The shrinking of liquid handling systems to the micron and submicron size range entails moving into the area of small Reynolds numbers. The fluid dynamics in this regime are very different from the macroscale. We present an intuitive explanation of how the different physics of small Reynolds numbers flow, along with microscopic sizes, can influence device design, and give examples from our own work using fluid flow in microfabricated devices designed for biological processing.

AB - The shrinking of liquid handling systems to the micron and submicron size range entails moving into the area of small Reynolds numbers. The fluid dynamics in this regime are very different from the macroscale. We present an intuitive explanation of how the different physics of small Reynolds numbers flow, along with microscopic sizes, can influence device design, and give examples from our own work using fluid flow in microfabricated devices designed for biological processing.

UR - https://www.scopus.com/pages/publications/0029769804

UR - https://www.scopus.com/pages/publications/0029769804#tab=citedBy

U2 - 10.1016/S0006-3495(96)79538-3

DO - 10.1016/S0006-3495(96)79538-3

M3 - Article

C2 - 8968612

AN - SCOPUS:0029769804

SN - 0006-3495

VL - 71

SP - 3430

EP - 3441

JO - Biophysical Journal

JF - Biophysical Journal

IS - 6

ER -

Biotechnology at low Reynolds numbers

Abstract

All Science Journal Classification (ASJC) codes

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