@article{92c965a7a6ce4018bc0785b96ba6419a,
title = "Biotechnology at low Reynolds numbers",
abstract = "The shrinking of liquid handling systems to the micron and submicron size range entails moving into the area of small Reynolds numbers. The fluid dynamics in this regime are very different from the macroscale. We present an intuitive explanation of how the different physics of small Reynolds numbers flow, along with microscopic sizes, can influence device design, and give examples from our own work using fluid flow in microfabricated devices designed for biological processing.",
author = "Brody, {James P.} and Paul Yager and Goldstein, {Raymond E.} and Austin, {Robert H.}",
note = "Funding Information: discussions. Acquisition and analysis of the rectangular flow velocity and hydrodynamic focusing profiles was done by Amulya Vamsi Madhav at Princeton. Microfabrication work was done both at the Washington Tech-nology Center and the Cornell Nanofabrication Facility. J. P. B. and P. Y. were supported by DARPA (through grant #DAMD17-94-J-4460), Senmed Medical Ventures, and the Washington Technology Center. R. E. G. was supported by NSF PFF Grant DMR93-50227 and the A. P. Sloan Foundation. R. H. A. was supported by a grant from the Office of Naval Research and unpaid bills at the Cornell Nanofabrication Facility.",
year = "1996",
month = dec,
doi = "10.1016/S0006-3495(96)79538-3",
language = "English (US)",
volume = "71",
pages = "3430--3441",
journal = "Biophysical Journal",
issn = "0006-3495",
publisher = "Elsevier B.V.",
number = "6",
}