Biosynthesis, Chemical Synthesis, and Pharmacological Evaluation of Lyngbyapeptin A as a GPCR Antagonist of Motilin, Cannabinoid, and Amylin Receptors

Keyphrases

• Chemical Synthesis 100%
• Methoxy 100%
• Cannabinoid Receptor 1 (CB1R) 100%
• Synthetic Evaluation 100%
• Pharmacological Evaluation 100%
• GPCR Antagonist 100%
• Motilin Receptor 100%
• Amylin Receptor 100%
• Biosynthetic Gene Clusters 50%
• Ketones 50%
• Tetrapeptide 50%
• Binding Assay 50%
• Cytotoxicity 50%
• Binding Mode 50%
• Papua New Guinea 50%
• Activity Profile 50%
• Marine Cyanobacteria 50%
• Acrylamide 50%
• Molecular Modeling 50%
• Arrestin 50%
• Modulating Activity 50%
• Functional Assay 50%
• Receptor 2 50%
• Guam 50%
• First Total Synthesis 50%
• Biological Testing 50%
• Desmethyl 50%
• Liquid-phase Peptide Synthesis 50%
• CALCR 50%
• CNR2 50%
• CNR1 50%
• Ketoanalogues 50%
• RAMP2 50%
• Compound 13 50%

Pharmacology, Toxicology and Pharmaceutical Science

• G Protein Coupled Receptor 100%
• Cannabinoid Receptor 100%
• Motilin Receptor 100%
• Amylin Receptor 100%
• Receptor 20%
• Cyanobacteria 20%
• Acrylamide 20%
• Cytotoxicity 20%
• Tetrapeptide 20%
• Retina S Antigen 20%
• Receptor Activity Modifying Protein 2 20%
• Peptide 20%
• Ketone 20%