Bioreductive alkylation as a trigger for toxic effects of dynemicin

Martin F. Semmelhack, J. Gallagher, D. Cohen

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

The endiyne derivative, dynemicin, is postulated to undergo bioreductive cis ring opening of a benzylic epoxide and activate the endiyne unit for Bergman rearrangement to an arene-1,4-diyl.

Original languageEnglish (US)
Pages (from-to)1521-1522
Number of pages2
JournalTetrahedron Letters
Volume31
Issue number11
DOIs
StatePublished - Jan 1 1990

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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