Bioreductive alkylation as a trigger for toxic effects of dynemicin

M. F. Semmelhack; J. Gallagher; D. Cohen

doi:10.1016/0040-4039(90)80005-7

Bioreductive alkylation as a trigger for toxic effects of dynemicin

M. F. Semmelhack, J. Gallagher, D. Cohen

Chemistry

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79 Scopus citations

Abstract

The endiyne derivative, dynemicin, is postulated to undergo bioreductive cis ring opening of a benzylic epoxide and activate the endiyne unit for Bergman rearrangement to an arene-1,4-diyl.

Original language	English (US)
Pages (from-to)	1521-1522
Number of pages	2
Journal	Tetrahedron Letters
Volume	31
Issue number	11
DOIs	https://doi.org/10.1016/0040-4039(90)80005-7
State	Published - 1990

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4039(90)80005-7

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title = "Bioreductive alkylation as a trigger for toxic effects of dynemicin",

abstract = "The endiyne derivative, dynemicin, is postulated to undergo bioreductive cis ring opening of a benzylic epoxide and activate the endiyne unit for Bergman rearrangement to an arene-1,4-diyl.",

author = "Semmelhack, {M. F.} and J. Gallagher and D. Cohen",

year = "1990",

doi = "10.1016/0040-4039(90)80005-7",

language = "English (US)",

volume = "31",

pages = "1521--1522",

journal = "Tetrahedron Letters",

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T1 - Bioreductive alkylation as a trigger for toxic effects of dynemicin

AU - Semmelhack, M. F.

AU - Gallagher, J.

AU - Cohen, D.

PY - 1990

Y1 - 1990

N2 - The endiyne derivative, dynemicin, is postulated to undergo bioreductive cis ring opening of a benzylic epoxide and activate the endiyne unit for Bergman rearrangement to an arene-1,4-diyl.

AB - The endiyne derivative, dynemicin, is postulated to undergo bioreductive cis ring opening of a benzylic epoxide and activate the endiyne unit for Bergman rearrangement to an arene-1,4-diyl.

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U2 - 10.1016/0040-4039(90)80005-7

DO - 10.1016/0040-4039(90)80005-7

M3 - Article

AN - SCOPUS:0025264829

SN - 0040-4039

VL - 31

SP - 1521

EP - 1522

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 11

ER -

Bioreductive alkylation as a trigger for toxic effects of dynemicin

Abstract

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