Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins

Brett R. Goldsmith, Joseph J. Mitala, Jesusa Josue, Ana Castro, Mitchell B. Lerner, Timothy H. Bayburt, Samuel M. Khamis, Ryan A. Jones, Joseph G. Brand, Stephen G. Sligar, Charles W. Luetje, Alan Gelperin, Paul A. Rhodes, Bohdana M. Discher, A. T.Charlie Johnson

Research output: Contribution to journalArticlepeer-review

159 Scopus citations


We have designed and implemented a practical nanoelectronic interface to G-protein coupled receptors (GPCRs), a large family of membrane proteins whose roles in the detection of molecules outside eukaryotic cells make them important pharmaceutical targets. Specifically, we have coupled olfactory receptor proteins (ORs) with carbon nanotube transistors. The resulting devices transduce signals associated with odorant binding to ORs in the gas phase under ambient conditions and show responses that are in excellent agreement with results from established assays for OR-ligand binding. The work represents significant progress on a path toward a bioelectronic nose that can be directly compared to biological olfactory systems as well as a general method for the study of GPCR function in multiple domains using electronic readout.

Original languageEnglish (US)
Pages (from-to)5408-5416
Number of pages9
JournalACS Nano
Issue number7
StatePublished - Jul 26 2011

All Science Journal Classification (ASJC) codes

  • General Engineering
  • General Materials Science
  • General Physics and Astronomy


  • bioelectronics
  • field effect transistor
  • nanotube
  • olfactory receptor proteins
  • vapor sensor


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