TY - JOUR
T1 - Biofuel powered glucose detection in bodily fluids with an n-type conjugated polymer
AU - Ohayon, David
AU - Nikiforidis, Georgios
AU - Savva, Achilleas
AU - Giugni, Andrea
AU - Wustoni, Shofarul
AU - Palanisamy, Tamilarasan
AU - Chen, Xingxing
AU - Maria, Iuliana Petruta
AU - Di Fabrizio, Enzo
AU - Costa, Pedro M.F.J.
AU - McCulloch, Iain
AU - Inal, Sahika
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - A promising class of materials for applications that rely on electron transfer for signal generation are the n-type semiconducting polymers. Here we demonstrate the integration of an n-type conjugated polymer with a redox enzyme for the autonomous detection of glucose and power generation from bodily fluids. The reversible, mediator-free, miniaturized glucose sensor is an enzyme-coupled organic electrochemical transistor with a detection range of six orders of magnitude. This n-type polymer is also used as an anode and paired with a polymeric cathode in an enzymatic fuel cell to convert the chemical energy of glucose and oxygen into electrical power. The all-polymer biofuel cell shows a performance that scales with the glucose content in the solution and a stability that exceeds 30 days. Moreover, at physiologically relevant glucose concentrations and from fluids such as human saliva, it generates enough power to operate an organic electrochemical transistor, thus contributes to the technological advancement of self-powered micrometre-scale sensors and actuators that run on metabolites produced in the body.
AB - A promising class of materials for applications that rely on electron transfer for signal generation are the n-type semiconducting polymers. Here we demonstrate the integration of an n-type conjugated polymer with a redox enzyme for the autonomous detection of glucose and power generation from bodily fluids. The reversible, mediator-free, miniaturized glucose sensor is an enzyme-coupled organic electrochemical transistor with a detection range of six orders of magnitude. This n-type polymer is also used as an anode and paired with a polymeric cathode in an enzymatic fuel cell to convert the chemical energy of glucose and oxygen into electrical power. The all-polymer biofuel cell shows a performance that scales with the glucose content in the solution and a stability that exceeds 30 days. Moreover, at physiologically relevant glucose concentrations and from fluids such as human saliva, it generates enough power to operate an organic electrochemical transistor, thus contributes to the technological advancement of self-powered micrometre-scale sensors and actuators that run on metabolites produced in the body.
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U2 - 10.1038/s41563-019-0556-4
DO - 10.1038/s41563-019-0556-4
M3 - Article
C2 - 31844278
AN - SCOPUS:85076915562
SN - 1476-1122
VL - 19
SP - 456
EP - 463
JO - Nature Materials
JF - Nature Materials
IS - 4
ER -