Biofilm streamers cause catastrophic disruption of flow with consequences for environmental and medical systems

Knut Drescher, Yi Shen, Bonnie Lynn Bassler, Howard A. Stone

Research output: Contribution to journalArticle

167 Scopus citations

Abstract

Biofilms are antibiotic-resistant, sessile bacterial communities that occupy most moist surfaces on Earth and cause chronic and medical device-associated infections. Despite their importance, basic information about biofilm dynamics in common ecological environments is lacking. Here, we demonstrate that flow through soil-like porous materials, industrial filters, and medical stents dramatically modifies the morphology of Pseudomonas aeruginosa biofilms to form 3D streamers, which, over time, bridge the spaces between obstacles and corners in nonuniform environments. We discovered that accumulation of surface-attached biofilm has little effect on flow through such environments, whereas biofilm streamers cause sudden and rapid clogging. We demonstrate that flow-induced shedding of extracellular matrix from surface-attached biofilms generates a sieve-like network that captures cells and other biomass, which add to the existing network, causing exponentially fast clogging independent of growth. These results suggest that biofilm streamers are ubiquitous in nature and strongly affect flow through porous materials in environmental, industrial, and medical systems.

Original languageEnglish (US)
Pages (from-to)4345-4350
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number11
DOIs
StatePublished - Mar 12 2013

All Science Journal Classification (ASJC) codes

  • General

Keywords

  • Bioclogging
  • Biofouling
  • Porous media

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