Biocompatible nanoparticle based on dextran-b-poly(L-lactide) block copolymer formed by flash nanoprecipitation

Mingwei Wang, Yisheng Xu, Jie Wang, Miaomiao Liu, Zhenyu Yuan, Kai Chen, Li Li, Robert K. Prud'homme, Xuhong Guo

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Biocompatible amphiphilic block copolymer dextran-bpoly(L-lactide) was synthesized by the end-to-end coupling of amino-terminated dextran and acryloyl-terminated poly(L-lactide). The dextran block copolymer was used to rapidly prepare nanoparticles encapsulating β-carotene through flash nanoprecipitation. The nanoparticle size can be tuned by different solvent ratios and stream velocities. The nanoparticles could be stably preserved for more than half a month, and an "anti-Ostwald" phenomenon was observed in the first week. The results indicate that flash nanoprecipitation is a promising method to prepare polysaccharide nanoparticles as drug carriers.

Original languageEnglish (US)
Pages (from-to)1688-1690
Number of pages3
JournalChemistry Letters
Volume44
Issue number12
DOIs
StatePublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Biocompatible nanoparticle based on dextran-b-poly(L-lactide) block copolymer formed by flash nanoprecipitation'. Together they form a unique fingerprint.

  • Cite this