@article{98eec9bc327b47d9a41d6b90149bf156,
title = "Biocompatible nanoparticle based on dextran-b-poly(L-lactide) block copolymer formed by flash nanoprecipitation",
abstract = "Biocompatible amphiphilic block copolymer dextran-bpoly(L-lactide) was synthesized by the end-to-end coupling of amino-terminated dextran and acryloyl-terminated poly(L-lactide). The dextran block copolymer was used to rapidly prepare nanoparticles encapsulating β-carotene through flash nanoprecipitation. The nanoparticle size can be tuned by different solvent ratios and stream velocities. The nanoparticles could be stably preserved for more than half a month, and an {"}anti-Ostwald{"} phenomenon was observed in the first week. The results indicate that flash nanoprecipitation is a promising method to prepare polysaccharide nanoparticles as drug carriers.",
author = "Mingwei Wang and Yisheng Xu and Jie Wang and Miaomiao Liu and Zhenyu Yuan and Kai Chen and Li Li and Prud'homme, {Robert K.} and Xuhong Guo",
note = "Funding Information: This work was supported by the NSFC Grants Nos. 51403062 and 51273063, the Fundamental Research Funds for the Central Universities, China Postdoctoral Science Foundation (No. 2013M541485), 111 Project Grant (No. B08021) and the Open Project of Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region (No. 2015BTRC001). We also would like to thank Nan Yang, Yuan Xu for their experimental help and Rulin Xiong for her help with GPC instruments. Publisher Copyright: {\textcopyright} 2015 The Chemical Society of Japan.",
year = "2015",
doi = "10.1246/cl.150800",
language = "English (US)",
volume = "44",
pages = "1688--1690",
journal = "Chemistry Letters",
issn = "0366-7022",
publisher = "Chemical Society of Japan",
number = "12",
}