Bidirectional extracellular matrix signaling during tissue morphogenesis

Nikolce Gjorevski, Celeste M. Nelson

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Normal tissue development and function are regulated by the interplay between cells and their surrounding extracellular matrix (ECM). The ECM provides biochemical and mechanical contextual information that is conveyed from the cell membrane through the cytoskeleton to the nucleus to direct cell phenotype. Cells, in turn, remodel the ECM and thereby sculpt their local microenvironment. Here we review the mechanisms by which cells interact with, respond to, and influence the ECM, with particular emphasis placed on the role of this bidirectional communication during tissue morphogenesis. We also discuss the implications for successful engineering of functional tissues ex vivo.

Original languageEnglish (US)
Pages (from-to)459-465
Number of pages7
JournalCytokine and Growth Factor Reviews
Volume20
Issue number5-6
DOIs
StatePublished - Oct 2009

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • Dynamic reciprocity
  • Mechanotransduction
  • Pattern formation

Fingerprint Dive into the research topics of 'Bidirectional extracellular matrix signaling during tissue morphogenesis'. Together they form a unique fingerprint.

  • Cite this