Bidirectional extracellular matrix signaling during tissue morphogenesis

Nikolce Gjorevski, Celeste M. Nelson

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Normal tissue development and function are regulated by the interplay between cells and their surrounding extracellular matrix (ECM). The ECM provides biochemical and mechanical contextual information that is conveyed from the cell membrane through the cytoskeleton to the nucleus to direct cell phenotype. Cells, in turn, remodel the ECM and thereby sculpt their local microenvironment. Here we review the mechanisms by which cells interact with, respond to, and influence the ECM, with particular emphasis placed on the role of this bidirectional communication during tissue morphogenesis. We also discuss the implications for successful engineering of functional tissues ex vivo.

Original languageEnglish (US)
Pages (from-to)459-465
Number of pages7
JournalCytokine and Growth Factor Reviews
Issue number5-6
StatePublished - Oct 2009

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology


  • Dynamic reciprocity
  • Mechanotransduction
  • Pattern formation


Dive into the research topics of 'Bidirectional extracellular matrix signaling during tissue morphogenesis'. Together they form a unique fingerprint.

Cite this