TY - JOUR
T1 - Bidirectional communication in oogenesis
T2 - a dynamic conversation in mice and Drosophila
AU - Doherty, Caroline A.
AU - Amargant, Farners
AU - Shvartsman, Stanislav Y.
AU - Duncan, Francesca E.
AU - Gavis, Elizabeth R.
N1 - Funding Information:
We thank Lucy Reading-Ikkanda (Flatiron Institute) for figure artwork, Trudi Schüpbach for helpful discussions, and the reviewers for insightful feedback. This work was supported by National Institutes of Health grants R35 GM126967 to E.R.G.; R01 HD093726 , R01 HD105752 , and R21 HD098498 to F.E.D.; and R01 GM134204 to S.Y.S. C.A.D. was supported by National Institutes of Health training grant T32 GM007388 and F.A. was supported by the Global Consortium for Reproductive Longevity and Equality ( GCRLE-1720 ) postdoctoral grant.
Funding Information:
We thank Lucy Reading-Ikkanda (Flatiron Institute) for figure artwork, Trudi Schüpbach for helpful discussions, and the reviewers for insightful feedback. This work was supported by National Institutes of Health grants R35 GM126967 to E.R.G.; R01 HD093726, R01 HD105752, and R21 HD098498 to F.E.D.; and R01 GM134204 to S.Y.S. C.A.D. was supported by National Institutes of Health training grant T32 GM007388 and F.A. was supported by the Global Consortium for Reproductive Longevity and Equality (GCRLE-1720) postdoctoral grant. The authors declare no competing interests.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2022/4
Y1 - 2022/4
N2 - In most animals, the oocyte is the largest cell by volume. The oocyte undergoes a period of large-scale growth during its development, prior to fertilization. At first glance, tissues that support the development of the oocyte in different organisms have diverse cellular characteristics that would seem to prohibit functional comparisons. However, these tissues often act with a common goal of establishing dynamic forms of two-way communication with the oocyte. We propose that this bidirectional communication between oocytes and support cells is a universal phenomenon that can be directly compared across species. Specifically, we highlight fruit fly and mouse oogenesis to demonstrate that similarities and differences in these systems should be used to inform and design future experiments in both models.
AB - In most animals, the oocyte is the largest cell by volume. The oocyte undergoes a period of large-scale growth during its development, prior to fertilization. At first glance, tissues that support the development of the oocyte in different organisms have diverse cellular characteristics that would seem to prohibit functional comparisons. However, these tissues often act with a common goal of establishing dynamic forms of two-way communication with the oocyte. We propose that this bidirectional communication between oocytes and support cells is a universal phenomenon that can be directly compared across species. Specifically, we highlight fruit fly and mouse oogenesis to demonstrate that similarities and differences in these systems should be used to inform and design future experiments in both models.
KW - bidirectional communication
KW - folliculogenesis
KW - oogenesis
KW - reproductive aging
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U2 - 10.1016/j.tcb.2021.11.005
DO - 10.1016/j.tcb.2021.11.005
M3 - Review article
C2 - 34922803
AN - SCOPUS:85121266333
SN - 0962-8924
VL - 32
SP - 311
EP - 323
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 4
ER -