@inbook{6e455e4acd8746ba870a5e76ce690d15,
title = "Biclustering of data matrices in systems biology via optimal re-ordering",
abstract = "In this work we present an optimal method for the biclustering data matrices in systems biology. Our approach is based on the iterative optimal re-ordering of submatrices to generate biclusters. A network flow model is presented for performing the row and column permutations for a specified objective function, which is general enough to accommodate many different metrics. The proposed biclustering approach is applied to a set of metabolite concentration data and we demonstrate that our methods arranges the metabolites in an order which more closely reflects their known metabolic functions and has the ability to classify related objects into groups.",
keywords = "Mixed-integer linear programming (MILP), biclustering, network flow, rearrangement clustering",
author = "DiMaggio, {Peter A.} and McAllister, {Scott R.} and Floudas, {Christodoulos A.} and Feng, {Xiao Jiang} and Rabinowitz, {Joshua D.} and Rabitz, {Herschel A.}",
year = "2008",
doi = "10.1016/S1570-7946(08)80100-9",
language = "English (US)",
isbn = "9780444532275",
series = "Computer Aided Chemical Engineering",
pages = "569--574",
editor = "Bertrand Braunschweig and Xavier Joulia",
booktitle = "18th European Symposium on Computer Aided Process Engineering",
}