TY - JOUR
T1 - Beyond self-reports
T2 - Changes in biomarkers as predictors of mortality
AU - Glei, Dana A.
AU - Goldman, Noreen
AU - Rodríguez, Germán
AU - Weinstein, Maxine
PY - 2014/6
Y1 - 2014/6
N2 - The proliferation of biosocial surveys has increased the importance of weighing the costs and benefits of adding biomarker collection to population-based surveys. A crucial question is whether biomarkers offer incremental value beyond self-reported measures, which are easier to collect and impose less respondent burden. We use longitudinal data from a nationally representative sample of older Taiwanese (aged 54+ in 2000, examined in 2000 and 2006 with mortality follow-up through 2011) to address that question with respect to predicting all-cause mortality. A summary measure of biomarkers improves mortality prediction (as measured by the area under the receiver operating characteristic curve) compared with self-reports alone, but individual biomarkers perform better than the summary score. We find that incorporating change in biomarkers over a six-year period yields a small improvement in mortality prediction compared with one-time measurement. But, is the incremental value worth the costs?.
AB - The proliferation of biosocial surveys has increased the importance of weighing the costs and benefits of adding biomarker collection to population-based surveys. A crucial question is whether biomarkers offer incremental value beyond self-reported measures, which are easier to collect and impose less respondent burden. We use longitudinal data from a nationally representative sample of older Taiwanese (aged 54+ in 2000, examined in 2000 and 2006 with mortality follow-up through 2011) to address that question with respect to predicting all-cause mortality. A summary measure of biomarkers improves mortality prediction (as measured by the area under the receiver operating characteristic curve) compared with self-reports alone, but individual biomarkers perform better than the summary score. We find that incorporating change in biomarkers over a six-year period yields a small improvement in mortality prediction compared with one-time measurement. But, is the incremental value worth the costs?.
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U2 - 10.1111/j.1728-4457.2014.00676.x
DO - 10.1111/j.1728-4457.2014.00676.x
M3 - Article
C2 - 25089065
AN - SCOPUS:84902304875
SN - 0098-7921
VL - 40
SP - 331
EP - 360
JO - Population and Development Review
JF - Population and Development Review
IS - 2
ER -