Behavioral evidence for the stimulation of CNS serotonin receptors by high doses of LSD

M. E. Trulson, C. A. Ross, B. L. Jacobs

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Systemic administration of lysergic acid diethylamide (LSD) to rats induces a behavioral syndrome consisting of tremor, rigidity, Straub tail, hindlimb abduction, lateral head weaving and reciprocal forepaw treading which is a reflection of increased activation of central serotonin receptors. Utilizing this behavioral measure, a marked supersensitivity to LSD was observed in rats whose serotonin nerve terminals had been selectively destroyed, and a dramatic tolerance to LSD was observed following its repeated administration to normal rats. These data provide direct evidence that LSD can stimulate CNS serotonin receptors to a degree which markedly affects behavior.

Original languageEnglish (US)
Pages (from-to)149-164
Number of pages16
JournalPsychopharmacology Communications
Volume2
Issue number2
StatePublished - Dec 1 1976

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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