TY - JOUR
T1 - Behavioral evidence for the rapid release of CNS serotonin by PCA and fenfluramine
AU - Trulson, Michael E.
AU - Jacobs, Barry L.
N1 - Funding Information:
This research was supported by Grants MH 23433 and MH 13445 from the National Institute of Mental Health, and the Spencer Foundation. We thank A.H. Robins Co. (fenfluramine) and Pfizer Inc. (p-chlorophenylalanine) for their generous gifts of drugs.
PY - 1976/3
Y1 - 1976/3
N2 - Administration of p-chloroamphetamine (PCA) (2.5-10.0 mg/kg) or fenfluramine (FF) (5.0-15.0 mg/kg) to rats induces a behavioral syndrome - consisting of tremor, rigidity, Straub tail, hindlimb abduction, lateral head weaving and reciprocal forepaw treading - which is a reflection of the activity of central serotonin-mediated synapses. The syndrome appears within 3-5 min following i.p. administration of PCA or FF, and the syndrome-inducing effects of PCA and FF are blocked by prior depletion of serotinin with p-chlorophenylalanine. By contrast, the syndrome-inducing effect of 5-methoxy-N,N-dimethyltryptamine (5-M-DMT), which directly stimulates postsynaptic serotonin receptors, is not changed by prior serotonin depletion. Catecholamine depletion with α-methyl-p-tyrosine produces essentially no change in the syndrome-inducing effects of PCA, FF or 5-M-DMT. These data indicate that the initial effect of PCA or FF administration is the rapid functional release of stored serotonin/.
AB - Administration of p-chloroamphetamine (PCA) (2.5-10.0 mg/kg) or fenfluramine (FF) (5.0-15.0 mg/kg) to rats induces a behavioral syndrome - consisting of tremor, rigidity, Straub tail, hindlimb abduction, lateral head weaving and reciprocal forepaw treading - which is a reflection of the activity of central serotonin-mediated synapses. The syndrome appears within 3-5 min following i.p. administration of PCA or FF, and the syndrome-inducing effects of PCA and FF are blocked by prior depletion of serotinin with p-chlorophenylalanine. By contrast, the syndrome-inducing effect of 5-methoxy-N,N-dimethyltryptamine (5-M-DMT), which directly stimulates postsynaptic serotonin receptors, is not changed by prior serotonin depletion. Catecholamine depletion with α-methyl-p-tyrosine produces essentially no change in the syndrome-inducing effects of PCA, FF or 5-M-DMT. These data indicate that the initial effect of PCA or FF administration is the rapid functional release of stored serotonin/.
KW - Behavioral syndrome
KW - Fenfluramine
KW - Serotonin release
KW - p-Chloroamphetamine
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U2 - 10.1016/0014-2999(76)90266-1
DO - 10.1016/0014-2999(76)90266-1
M3 - Article
C2 - 131036
AN - SCOPUS:0017252964
SN - 0014-2999
VL - 36
SP - 149
EP - 154
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -