Basal forebrain neurons undergo somatal and dendritic remodeling during postnatal development: a single-section Golgi and choline acetyltransferase analysis

Elizabeth Gould, Todd W. Farris, Larry L. Butcher

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

In an attempt to determine whether or not morphologic changes occur in the cholinergic basal forebrain during postnatal development, Golgi-impregnated and choline acetyltransferase-positive cells were examined in adult and postnatal day (P) 10, 14, 18, and 27 rats. Light microscopic analyses revealed progressive increases in cross-sectional cell body area, number of primary dendrites, number of dendritic branch points, and length of the longest dendrite that peaked at P18 and thereafter decreased to smaller adult values with the exception of dendritic length which monotonically increased until adulthood. These findings suggest that extensive remodeling of cholinergic neurons in the basal nuclear complex occurs even at relatively late postnatal periods.

Original languageEnglish (US)
Pages (from-to)297-302
Number of pages6
JournalDevelopmental Brain Research
Volume46
Issue number2
DOIs
StatePublished - Apr 1 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology

Keywords

  • Choline acetyltransferase
  • Cholinergic neuron
  • Dendrite
  • Development
  • Golgi impregnation
  • Nucleus basalis

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