TY - JOUR
T1 - Barriers to hepatitis C virus infection in mice
AU - Schwoerer, Michael P.
AU - Ploss, Alexander
N1 - Funding Information:
Work in the laboratory is supported in part by grants from the National Institutes of Health ( R01AI138797 , R01AI107301 , R01AI146917 , R01AI153236 , R01AI168048 ), and funds from Princeton University. M.P.S. is supported by the NIGMS of the National Institutes of Health under grant number T32GM007388 and a HMEI-STEP fellowship from the High Meadows Environmental Institute at Princeton University.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/10
Y1 - 2022/10
N2 - Hepatitis C virus (HCV) is unable to infect mice, a fact that has severely limited their use as small-animal models for HCV pathogenesis and as tools for HCV vaccine development. HCV is blocked at various stages of its life cycle in mouse cells, due to incompatibility with host factors, the presence of dominant restriction factors, and effective immune responses. Molecular mechanisms for several such blocks have been characterized. The stepwise understanding of these limitations in mice will enable the development of an immunocompetent mouse that can fully support HCV infection and exhibit disease similar to that of infected humans.
AB - Hepatitis C virus (HCV) is unable to infect mice, a fact that has severely limited their use as small-animal models for HCV pathogenesis and as tools for HCV vaccine development. HCV is blocked at various stages of its life cycle in mouse cells, due to incompatibility with host factors, the presence of dominant restriction factors, and effective immune responses. Molecular mechanisms for several such blocks have been characterized. The stepwise understanding of these limitations in mice will enable the development of an immunocompetent mouse that can fully support HCV infection and exhibit disease similar to that of infected humans.
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U2 - 10.1016/j.coviro.2022.101273
DO - 10.1016/j.coviro.2022.101273
M3 - Review article
C2 - 36244239
AN - SCOPUS:85139736708
SN - 1879-6257
VL - 56
JO - Current Opinion in Virology
JF - Current Opinion in Virology
M1 - 101273
ER -