Barriers of hepatitis C virus interspecies transmission

Lisa Sandmann, Alexander Ploss

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Hepatitis C virus (HCV) is a major causative agent of severe liver disease including fibrosis, cirrhosis and liver cancer. Therapy has improved over the years, but continues to be associated with adverse side effects and variable success rates. Furthermore, a vaccine protecting against HCV infection remains elusive. Development of more effective intervention measures has been delayed by the lack of a suitable animal model. Naturally, HCV infects only humans and chimpanzees. The determinants of this limited host range are poorly understood in part due to difficulties of studying HCV in cell culture. Some progress has been made elucidating the barriers for the HCV lifecycle in non-permissive species which will help in the future to construct animal models for HCV infection, immunity and pathogenesis.

Original languageEnglish (US)
Pages (from-to)70-80
Number of pages11
JournalVirology
Volume435
Issue number1
DOIs
StatePublished - Jan 5 2013

All Science Journal Classification (ASJC) codes

  • Virology

Keywords

  • Animal models
  • Drug development
  • Hepatitis C virus
  • Humanized mice
  • Pathogenesis
  • Species tropism
  • Vaccine development

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