Abstract
The aza-Diels-Alder reactions of 2-iodo-3-indoleacetaldehydes in the presence of zinc triflate provides 2-(2-iodoindolylmethyl)-4-pyridones in high yield. Palladium-mediated intramolecular Heck cyclization gives access to the tetracyclic tetrahydro-β-carboline framework of the ajmaline/sarpagine alkaloids.
Original language | English (US) |
---|---|
Pages (from-to) | 3871-3874 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 43 |
Issue number | 21 |
DOIs | |
State | Published - May 20 2002 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry