Axonal spread of neuroinvasive viral infections

Matthew P. Taylor, Lynn W. Enquist

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Neuroinvasive viral infections invade the nervous system, often eliciting serious disease and death. Members of four viral families are both neuroinvasive and capable of transmitting progeny virions or virion components within the long neuronal extensions known as axons. Axons provide physical structures that enable viral infection to spread within the host while avoiding extracellular immune responses. Technological advances in the analysis of in vivo neural circuits, neuronal culturing, and live imaging of fluorescent fusion proteins have enabled an unprecedented view into the steps of virion assembly, transport, and egress involved in axonal spread. In this review we summarize the literature supporting anterograde (axon to cell) spread of viral infection, describe the various strategies of virion transport, and discuss the effects of spread on populations of neuroinvasive viruses.

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalTrends in Microbiology
Volume23
Issue number5
DOIs
StatePublished - May 1 2015

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Keywords

  • Alpha herpesvirus
  • Anterograde-directed spread
  • Axon
  • Flavivirus
  • Neuron
  • Picornavirus
  • Rhabdovirus

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