Auxiliary-mediated site-specific peptide ubiquitylation

Champak Chatterjee; Robert K. McGinty; Jean Philippe Pellois; Tom W. Muir

doi:10.1002/anie.200605155

Auxiliary-mediated site-specific peptide ubiquitylation

Champak Chatterjee
, Robert K. McGinty
, Jean Philippe Pellois
, Tom W. Muir

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

(Chemical Equation Presented) Lighting up ubiquitylation: A photolytically removable ligation auxiliary (Aux) was employed for the site-specific attachment of ubiquitin (Ub) to one of three lysine residues in a C-terminal peptide fragment of histone H2B (cH2B). Following photolysis, the ligation product was a viable substrate for the ubiquitin C-terminal hydrolase UCH-L3.

Original language	English (US)
Pages (from-to)	2814-2818
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	16
DOIs	https://doi.org/10.1002/anie.200605155
State	Published - 2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Chemistry
Catalysis

Keywords

Ligation auxiliaries
Peptides
Semisynthesis
Ubiquitylation

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10.1002/anie.200605155

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title = "Auxiliary-mediated site-specific peptide ubiquitylation",

abstract = "(Chemical Equation Presented) Lighting up ubiquitylation: A photolytically removable ligation auxiliary (Aux) was employed for the site-specific attachment of ubiquitin (Ub) to one of three lysine residues in a C-terminal peptide fragment of histone H2B (cH2B). Following photolysis, the ligation product was a viable substrate for the ubiquitin C-terminal hydrolase UCH-L3.",

keywords = "Ligation auxiliaries, Peptides, Semisynthesis, Ubiquitylation",

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AU - Chatterjee, Champak

AU - McGinty, Robert K.

AU - Pellois, Jean Philippe

AU - Muir, Tom W.

PY - 2007

Y1 - 2007

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KW - Ligation auxiliaries

KW - Peptides

KW - Semisynthesis

KW - Ubiquitylation

UR - https://www.scopus.com/pages/publications/34250880139

UR - https://www.scopus.com/pages/publications/34250880139#tab=citedBy

U2 - 10.1002/anie.200605155

DO - 10.1002/anie.200605155

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AN - SCOPUS:34250880139

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

Auxiliary-mediated site-specific peptide ubiquitylation

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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