Abstract
(Chemical Equation Presented) Lighting up ubiquitylation: A photolytically removable ligation auxiliary (Aux) was employed for the site-specific attachment of ubiquitin (Ub) to one of three lysine residues in a C-terminal peptide fragment of histone H2B (cH2B). Following photolysis, the ligation product was a viable substrate for the ubiquitin C-terminal hydrolase UCH-L3.
Original language | English (US) |
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Pages (from-to) | 2814-2818 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 46 |
Issue number | 16 |
DOIs | |
State | Published - 2007 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Catalysis
- Chemistry(all)
Keywords
- Ligation auxiliaries
- Peptides
- Semisynthesis
- Ubiquitylation