Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis

Eric Wieschaus; Robert Riggleman

doi:10.1016/0092-8674(87)90558-7

Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis

Eric Wieschaus
, Robert Riggleman

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

Embryos hemizygous for armadillo produce a "segment polarity" phenotype in which the naked posterior two-thirds of each segment is replaced by denticles with reversed polarity. Small patches of homozygous arm cells induced by mitotic recombination also form such denticles, indicating that the changes in cellular fate observed in homozygous arm embryos are autonomous at the level of single cells. Clonally derived arm patches do not, however, show the characteristic arm polarity reversals, arguing that this feature of the phenotype depends on cell interactions in fully mutant embryos. Few, if any, clones were found in the posterior-most regions of the naked cuticle, and none were found in the posterior compartments of the thorax.

Original language	English (US)
Pages (from-to)	177-184
Number of pages	8
Journal	Cell
Volume	49
Issue number	2
DOIs	https://doi.org/10.1016/0092-8674(87)90558-7
State	Published - Apr 24 1987

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/0092-8674(87)90558-7

Cite this

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title = "Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis",

abstract = "Embryos hemizygous for armadillo produce a {"}segment polarity{"} phenotype in which the naked posterior two-thirds of each segment is replaced by denticles with reversed polarity. Small patches of homozygous arm cells induced by mitotic recombination also form such denticles, indicating that the changes in cellular fate observed in homozygous arm embryos are autonomous at the level of single cells. Clonally derived arm patches do not, however, show the characteristic arm polarity reversals, arguing that this feature of the phenotype depends on cell interactions in fully mutant embryos. Few, if any, clones were found in the posterior-most regions of the naked cuticle, and none were found in the posterior compartments of the thorax.",

author = "Eric Wieschaus and Robert Riggleman",

note = "Funding Information: We thank our colleagues at Princeton for many helpful comments on the manuscript and Nick Baker, Norbert Perrimon, Alfonso Martinez-Arias, and Bob Holmgren for sharing unpublished data with us. The experiments were supported by a National Institutes of Health Research Grant (PHS HD15567) to E. W.",

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T1 - Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis

AU - Wieschaus, Eric

AU - Riggleman, Robert

N1 - Funding Information: We thank our colleagues at Princeton for many helpful comments on the manuscript and Nick Baker, Norbert Perrimon, Alfonso Martinez-Arias, and Bob Holmgren for sharing unpublished data with us. The experiments were supported by a National Institutes of Health Research Grant (PHS HD15567) to E. W.

PY - 1987/4/24

Y1 - 1987/4/24

N2 - Embryos hemizygous for armadillo produce a "segment polarity" phenotype in which the naked posterior two-thirds of each segment is replaced by denticles with reversed polarity. Small patches of homozygous arm cells induced by mitotic recombination also form such denticles, indicating that the changes in cellular fate observed in homozygous arm embryos are autonomous at the level of single cells. Clonally derived arm patches do not, however, show the characteristic arm polarity reversals, arguing that this feature of the phenotype depends on cell interactions in fully mutant embryos. Few, if any, clones were found in the posterior-most regions of the naked cuticle, and none were found in the posterior compartments of the thorax.

AB - Embryos hemizygous for armadillo produce a "segment polarity" phenotype in which the naked posterior two-thirds of each segment is replaced by denticles with reversed polarity. Small patches of homozygous arm cells induced by mitotic recombination also form such denticles, indicating that the changes in cellular fate observed in homozygous arm embryos are autonomous at the level of single cells. Clonally derived arm patches do not, however, show the characteristic arm polarity reversals, arguing that this feature of the phenotype depends on cell interactions in fully mutant embryos. Few, if any, clones were found in the posterior-most regions of the naked cuticle, and none were found in the posterior compartments of the thorax.

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Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis

Abstract

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