TY - JOUR
T1 - Autonomous requirements for the segment polarity gene armadillo during Drosophila embryogenesis
AU - Wieschaus, Eric
AU - Riggleman, Robert
N1 - Funding Information:
We thank our colleagues at Princeton for many helpful comments on the manuscript and Nick Baker, Norbert Perrimon, Alfonso Martinez-Arias, and Bob Holmgren for sharing unpublished data with us. The experiments were supported by a National Institutes of Health Research Grant (PHS HD15567) to E. W.
PY - 1987/4/24
Y1 - 1987/4/24
N2 - Embryos hemizygous for armadillo produce a "segment polarity" phenotype in which the naked posterior two-thirds of each segment is replaced by denticles with reversed polarity. Small patches of homozygous arm cells induced by mitotic recombination also form such denticles, indicating that the changes in cellular fate observed in homozygous arm embryos are autonomous at the level of single cells. Clonally derived arm patches do not, however, show the characteristic arm polarity reversals, arguing that this feature of the phenotype depends on cell interactions in fully mutant embryos. Few, if any, clones were found in the posterior-most regions of the naked cuticle, and none were found in the posterior compartments of the thorax.
AB - Embryos hemizygous for armadillo produce a "segment polarity" phenotype in which the naked posterior two-thirds of each segment is replaced by denticles with reversed polarity. Small patches of homozygous arm cells induced by mitotic recombination also form such denticles, indicating that the changes in cellular fate observed in homozygous arm embryos are autonomous at the level of single cells. Clonally derived arm patches do not, however, show the characteristic arm polarity reversals, arguing that this feature of the phenotype depends on cell interactions in fully mutant embryos. Few, if any, clones were found in the posterior-most regions of the naked cuticle, and none were found in the posterior compartments of the thorax.
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U2 - 10.1016/0092-8674(87)90558-7
DO - 10.1016/0092-8674(87)90558-7
M3 - Article
C2 - 3105892
AN - SCOPUS:0023663371
SN - 0092-8674
VL - 49
SP - 177
EP - 184
JO - Cell
JF - Cell
IS - 2
ER -