Aurora A, meiosis and mitosis

Richard Crane, Bedrick Gadea, Laurie Littlepage, Hua Wu, Joan V. Ruderman

Research output: Contribution to journalShort surveypeer-review

145 Scopus citations

Abstract

The Aurora family kinases are pivotal to the successful execution of cell division. Together they ensure the formation of a bipolar mitotic spindle, accurate segregation of chromosomes and the completion of cytokinesis. They are also attractive drug targets, being frequently deregulated in cancer and able to transform cells in vitro. In this review, we summarize current knowledge about the three family members, Aur-A, Aur-B and Aur-C. We then focus on Aur-A, its roles in mitotic progression, and its emerging roles in checkpoint control pathways. Aur-A activity can be controlled at several levels, including phosphorylation, ubiquitin-dependent proteolysis and interaction with both positive regulators, such as TPX2, and negative ones, like the tumor suppressor protein p53. In addition, work in Xenopus oocytes and early embryos has revealed a second role for Aur-A, directing the polyadenylation-dependent translation of specific mRNAs important for cell cycle progression. This function extends to post-mitotic neurons, and perhaps even to cycling somatic cells.

Original languageEnglish (US)
Pages (from-to)215-229
Number of pages15
JournalBiology of the Cell
Volume96
Issue number3
DOIs
StatePublished - Apr 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology

Keywords

  • Aurora
  • Meiosis
  • Mitosis
  • Oocyte
  • Xenopus

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