The addition of 2-lithio-2-methylpropionitrile (1) to chirally modified η6-arene-tricarbonylchromium complexes (5) leads to the formation of 2-(cyclohex-2-en-1-on-5-yl)-2-methylpropionitrile (4) in good yields and, under thermodynamically controlled conditions, with up to 48% ee.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Apr 29 1996|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry