Asymmetric induction in the nucleophile addition to η6-arene-tricarbonyl-chromium(0) complexes

M. F. Semmelhack, Hans Günther Schmalz

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39 Scopus citations


The addition of 2-lithio-2-methylpropionitrile (1) to chirally modified η6-arene-tricarbonylchromium complexes (5) leads to the formation of 2-(cyclohex-2-en-1-on-5-yl)-2-methylpropionitrile (4) in good yields and, under thermodynamically controlled conditions, with up to 48% ee.

Original languageEnglish (US)
Pages (from-to)3089-3092
Number of pages4
JournalTetrahedron Letters
Issue number18
StatePublished - Apr 29 1996

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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