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Asymmetric hydrogenation of tetrahydropyrazines: Synthesis of (S)-piperazine-2-tert-butylcarboxamide, an intermediate in the preparation of the HIV protease inhibitor indinavir

  • K. Rossen
  • , Steven A. Weissman
  • , J. Sager
  • , R. A. Reamer
  • , D. Askin
  • , R. P. Volante
  • , P. J. Reider

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Pharmacology, Toxicology and Pharmaceutical Science