Asymmetric hydrogenation of 3-alkylidene-2-piperidones using Noyori's catalyst. Effect of N-substituents on the enantioselectivity

John Y.L. Chung, Dalian Zhao, David L. Hughes, James M. McNamara, Edward J.J. Grabowski, Paul J. Reider

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The enantioselectivity in the asymmetric hydrogenation of 3-alkylidene-2-piperidones catalyzed by BINAP-Ru(II) complex was found to be significantly effected by the internal substituents on the lactam nitrogen, affording the corresponding 3-alkyl-2-piperidones in 52-92% ee.

Original languageEnglish (US)
Pages (from-to)7379-7382
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number41
DOIs
StatePublished - Oct 9 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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