Asymmetric aza-Diels-Alder reactions of indole 2-carboxaldehydes

Jeffrey T. Kuethe; Ian W. Davies; Peter G. Dormer; Robert A. Reamer; David J. Mathre; Paul J. Reider

doi:10.1016/S0040-4039(01)02070-6

Asymmetric aza-Diels-Alder reactions of indole 2-carboxaldehydes

Jeffrey T. Kuethe, Ian W. Davies, Peter G. Dormer, Robert A. Reamer, David J. Mathre, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The aza-Diels-Alder reaction of substituted indole 2-carboxaldehydes with Danishefsky's diene has been investigated. The reaction proceeds with a high degree of diastereoselectivity providing highly functionalized 2-(2-piperidyl)indoles which are further elaborated into novel polycyclic heterocycles.

Original language	English (US)
Pages (from-to)	29-32
Number of pages	4
Journal	Tetrahedron Letters
Volume	43
Issue number	1
DOIs	https://doi.org/10.1016/S0040-4039(01)02070-6
State	Published - Jan 1 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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Cite this

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abstract = "The aza-Diels-Alder reaction of substituted indole 2-carboxaldehydes with Danishefsky's diene has been investigated. The reaction proceeds with a high degree of diastereoselectivity providing highly functionalized 2-(2-piperidyl)indoles which are further elaborated into novel polycyclic heterocycles.",

author = "Kuethe, \{Jeffrey T.\} and Davies, \{Ian W.\} and Dormer, \{Peter G.\} and Reamer, \{Robert A.\} and Mathre, \{David J.\} and Reider, \{Paul J.\}",

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AU - Kuethe, Jeffrey T.

AU - Davies, Ian W.

AU - Dormer, Peter G.

AU - Reamer, Robert A.

AU - Mathre, David J.

AU - Reider, Paul J.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - The aza-Diels-Alder reaction of substituted indole 2-carboxaldehydes with Danishefsky's diene has been investigated. The reaction proceeds with a high degree of diastereoselectivity providing highly functionalized 2-(2-piperidyl)indoles which are further elaborated into novel polycyclic heterocycles.

AB - The aza-Diels-Alder reaction of substituted indole 2-carboxaldehydes with Danishefsky's diene has been investigated. The reaction proceeds with a high degree of diastereoselectivity providing highly functionalized 2-(2-piperidyl)indoles which are further elaborated into novel polycyclic heterocycles.

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U2 - 10.1016/S0040-4039(01)02070-6

DO - 10.1016/S0040-4039(01)02070-6

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AN - SCOPUS:0036134486

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 1

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Asymmetric aza-Diels-Alder reactions of indole 2-carboxaldehydes

Abstract

All Science Journal Classification (ASJC) codes

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