Asymmetric aza-Diels-Alder reactions of indole 2-carboxaldehydes

Jeffrey T. Kuethe; Ian W. Davies; Peter G. Dormer; Robert A. Reamer; David J. Mathre; Paul J. Reider

doi:10.1016/S0040-4039(01)02070-6

Asymmetric aza-Diels-Alder reactions of indole 2-carboxaldehydes

Jeffrey T. Kuethe, Ian W. Davies, Peter G. Dormer, Robert A. Reamer, David J. Mathre, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The aza-Diels-Alder reaction of substituted indole 2-carboxaldehydes with Danishefsky's diene has been investigated. The reaction proceeds with a high degree of diastereoselectivity providing highly functionalized 2-(2-piperidyl)indoles which are further elaborated into novel polycyclic heterocycles.

Original language	English (US)
Pages (from-to)	29-32
Number of pages	4
Journal	Tetrahedron Letters
Volume	43
Issue number	1
DOIs	https://doi.org/10.1016/S0040-4039(01)02070-6
State	Published - Jan 1 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(01)02070-6

Cite this

@article{9c3cca09f0fb4d4792a2c70816c2a773,

title = "Asymmetric aza-Diels-Alder reactions of indole 2-carboxaldehydes",

abstract = "The aza-Diels-Alder reaction of substituted indole 2-carboxaldehydes with Danishefsky's diene has been investigated. The reaction proceeds with a high degree of diastereoselectivity providing highly functionalized 2-(2-piperidyl)indoles which are further elaborated into novel polycyclic heterocycles.",

author = "Kuethe, {Jeffrey T.} and Davies, {Ian W.} and Dormer, {Peter G.} and Reamer, {Robert A.} and Mathre, {David J.} and Reider, {Paul J.}",

year = "2002",

month = jan,

day = "1",

doi = "10.1016/S0040-4039(01)02070-6",

language = "English (US)",

volume = "43",

pages = "29--32",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "1",

}

TY - JOUR

T1 - Asymmetric aza-Diels-Alder reactions of indole 2-carboxaldehydes

AU - Kuethe, Jeffrey T.

AU - Davies, Ian W.

AU - Dormer, Peter G.

AU - Reamer, Robert A.

AU - Mathre, David J.

AU - Reider, Paul J.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - The aza-Diels-Alder reaction of substituted indole 2-carboxaldehydes with Danishefsky's diene has been investigated. The reaction proceeds with a high degree of diastereoselectivity providing highly functionalized 2-(2-piperidyl)indoles which are further elaborated into novel polycyclic heterocycles.

AB - The aza-Diels-Alder reaction of substituted indole 2-carboxaldehydes with Danishefsky's diene has been investigated. The reaction proceeds with a high degree of diastereoselectivity providing highly functionalized 2-(2-piperidyl)indoles which are further elaborated into novel polycyclic heterocycles.

UR - http://www.scopus.com/inward/record.url?scp=0036134486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036134486&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(01)02070-6

DO - 10.1016/S0040-4039(01)02070-6

M3 - Article

AN - SCOPUS:0036134486

SN - 0040-4039

VL - 43

SP - 29

EP - 32

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 1

ER -

Asymmetric aza-Diels-Alder reactions of indole 2-carboxaldehydes

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this