Asymmetric aza-Diels-Alder reactions of indole 2-carboxaldehydes

Jeffrey T. Kuethe, Ian W. Davies, Peter G. Dormer, Robert A. Reamer, David J. Mathre, Paul J. Reider

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The aza-Diels-Alder reaction of substituted indole 2-carboxaldehydes with Danishefsky's diene has been investigated. The reaction proceeds with a high degree of diastereoselectivity providing highly functionalized 2-(2-piperidyl)indoles which are further elaborated into novel polycyclic heterocycles.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number1
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Asymmetric aza-Diels-Alder reactions of indole 2-carboxaldehydes'. Together they form a unique fingerprint.

  • Cite this

    Kuethe, J. T., Davies, I. W., Dormer, P. G., Reamer, R. A., Mathre, D. J., & Reider, P. J. (2002). Asymmetric aza-Diels-Alder reactions of indole 2-carboxaldehydes. Tetrahedron Letters, 43(1), 29-32. https://doi.org/10.1016/S0040-4039(01)02070-6