Asymmetric aza-Diels-Alder reactions of indole 2-carboxaldehydes

Jeffrey T. Kuethe, Ian W. Davies, Peter G. Dormer, Robert A. Reamer, David J. Mathre, Paul J. Reider

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The aza-Diels-Alder reaction of substituted indole 2-carboxaldehydes with Danishefsky's diene has been investigated. The reaction proceeds with a high degree of diastereoselectivity providing highly functionalized 2-(2-piperidyl)indoles which are further elaborated into novel polycyclic heterocycles.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalTetrahedron Letters
Issue number1
StatePublished - Jan 1 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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