Assessment of Oxidative Stress in Patients with an Isolated Traumatic Brain Injury Using Disposable Electrochemical Test Strips

Leonard T. Rael, Raphael Bar-Or, Michael T. Kelly, Matthew M. Carrick, David Bar-Or

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The barriers to using plasma redox potential as a measure of oxidative stress in patients are the use of specialized equipment, necessity of sterilization between tests, and inconsistent electrode surfaces and cell geometry. These problems are resolved using disposable test strips with built in electrochemical cells. Measuring the electrode potential at a small current yields a stable value that is ~50mV higher for isolated traumatic brain injury (ITBI) patients than for healthy individuals. Even with natural variations within blood chemistry, this simple method may be clinically useful for assessing the degree of oxidative stress and injury severity in ITBI patients.

Original languageEnglish (US)
Pages (from-to)2567-2573
Number of pages7
JournalElectroanalysis
Volume27
Issue number11
DOIs
StatePublished - Nov 1 2015

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Electrochemistry

Keywords

  • Human plasma
  • Isolated traumatic brain injury
  • Oxidative stress
  • Redox chemistry
  • Sensors

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