The tremendous value artificial intelligence (AI) is showing across a broad range of applications is driving it from cyber-systems to systems pervading every aspect of our lives. But real-world data challenges the efficiency and robustness with which AI systems of today can perform, due to the highly dynamic and noisy scenarios they face. While algorithmic solutions are required, this paper also explores technological solutions based on large-scale sensing. Specifically, Large-Area Electronics (LAE) is a technology that can make large-scale, form-fitting sensors possible for broad deployment in our lives. System-design principles, architectural approaches, supporting circuits, and underlying technological concerns surrounding LAE and its use in emerging systems for intelligent sensing are explored.