Architectural self-construction in nature and chemical synthesis

Erik J. Sorensen

doi:10.1016/S0968-0896(03)00185-8

Architectural self-construction in nature and chemical synthesis

Erik J. Sorensen

Research output: Contribution to journal › Short survey › peer-review

20 Scopus citations

Abstract

The chemistry of squalene oxide (1) exemplifies that architectural complexity can be encoded in the structures of relatively simple, polyunsaturated molecules. When the concept of architectural self-construction is an integral part of the design of a chemical synthesis, powerful strategies can be uncovered. this article addresses studies which showed that polyunsaturated, 19-membered ring carbocycle contains all of the molecular information that is required to give the stereochemically complex polycyclic architecture of the cytotoxic natural product FR182877.

Original language	English (US)
Pages (from-to)	3225-3228
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry
Volume	11
Issue number	15
DOIs	https://doi.org/10.1016/S0968-0896(03)00185-8
State	Published - Jul 31 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Drug Discovery
Molecular Medicine
Molecular Biology
Biochemistry
Clinical Biochemistry
Pharmaceutical Science
Organic Chemistry

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10.1016/S0968-0896(03)00185-8

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title = "Architectural self-construction in nature and chemical synthesis",

abstract = "The chemistry of squalene oxide (1) exemplifies that architectural complexity can be encoded in the structures of relatively simple, polyunsaturated molecules. When the concept of architectural self-construction is an integral part of the design of a chemical synthesis, powerful strategies can be uncovered. this article addresses studies which showed that polyunsaturated, 19-membered ring carbocycle contains all of the molecular information that is required to give the stereochemically complex polycyclic architecture of the cytotoxic natural product FR182877.",

author = "Sorensen, {Erik J.}",

note = "Funding Information: The author gratefully acknowledges stimulating discussions with Professors Albert Eschenmoser and M. G. Finn. This work was supported by NIH/NCI Grant CA85526, the Beckman Foundation, The Skaggs Institute for Chemical Biology at The Scripps Research Institute, a Camille-Dreyfus Teacher-Scholar Award, and research awards from AstraZeneca, Lilly, Pfizer, and Merck.",

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AU - Sorensen, Erik J.

N1 - Funding Information: The author gratefully acknowledges stimulating discussions with Professors Albert Eschenmoser and M. G. Finn. This work was supported by NIH/NCI Grant CA85526, the Beckman Foundation, The Skaggs Institute for Chemical Biology at The Scripps Research Institute, a Camille-Dreyfus Teacher-Scholar Award, and research awards from AstraZeneca, Lilly, Pfizer, and Merck.

PY - 2003/7/31

Y1 - 2003/7/31

N2 - The chemistry of squalene oxide (1) exemplifies that architectural complexity can be encoded in the structures of relatively simple, polyunsaturated molecules. When the concept of architectural self-construction is an integral part of the design of a chemical synthesis, powerful strategies can be uncovered. this article addresses studies which showed that polyunsaturated, 19-membered ring carbocycle contains all of the molecular information that is required to give the stereochemically complex polycyclic architecture of the cytotoxic natural product FR182877.

AB - The chemistry of squalene oxide (1) exemplifies that architectural complexity can be encoded in the structures of relatively simple, polyunsaturated molecules. When the concept of architectural self-construction is an integral part of the design of a chemical synthesis, powerful strategies can be uncovered. this article addresses studies which showed that polyunsaturated, 19-membered ring carbocycle contains all of the molecular information that is required to give the stereochemically complex polycyclic architecture of the cytotoxic natural product FR182877.

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DO - 10.1016/S0968-0896(03)00185-8

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EP - 3228

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 15

ER -

Architectural self-construction in nature and chemical synthesis

Abstract

All Science Journal Classification (ASJC) codes

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