Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria

Michael F. Green; Keith H. Nuechterlein; James M. Gold; Deanna M. Barch; Jonathan D. Cohen; Susan Essock; Wayne S. Fenton; Fred Frese; Terry E. Goldberg; Robert K. Heaton; Richard S.E. Keefe; Robert S. Kern; Helena Kraemer; Ellen Stover; Daniel R. Weinberger; Steven Zalcman; Stephen R. Marder

doi:10.1016/j.biopsych.2004.06.023

Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria

Michael F. Green, Keith H. Nuechterlein, James M. Gold, Deanna M. Barch, Jonathan D. Cohen, Susan Essock, Wayne S. Fenton, Fred Frese, Terry E. Goldberg, Robert K. Heaton, Richard S.E. Keefe, Robert S. Kern, Helena Kraemer, Ellen Stover, Daniel R. Weinberger, Steven Zalcman, Stephen R. Marder

Research output: Contribution to journal › Review article › peer-review

789 Scopus citations

Abstract

To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) established the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference. The goals of the meeting were to 1) identify the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literature and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory, reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability, high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/ tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia.

Original language	English (US)
Pages (from-to)	301-307
Number of pages	7
Journal	Biological Psychiatry
Volume	56
Issue number	5
DOIs	https://doi.org/10.1016/j.biopsych.2004.06.023
State	Published - Sep 1 2004

All Science Journal Classification (ASJC) codes

Biological Psychiatry

Keywords

Cognition
cognitive assessment
cognitive enhancement
neurocognition
psychopharmacology
schizophrenia

Access to Document

10.1016/j.biopsych.2004.06.023

Cite this

Green, M. F., Nuechterlein, K. H., Gold, J. M., Barch, D. M., Cohen, J. D., Essock, S., Fenton, W. S., Frese, F., Goldberg, T. E., Heaton, R. K., Keefe, R. S. E., Kern, R. S., Kraemer, H., Stover, E., Weinberger, D. R., Zalcman, S., & Marder, S. R. (2004). Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria. Biological Psychiatry, 56(5), 301-307. https://doi.org/10.1016/j.biopsych.2004.06.023

@article{acbfb4963d3a430180a5ea6bcb91e427,

title = "Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria",

abstract = "To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) established the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference. The goals of the meeting were to 1) identify the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literature and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory, reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability, high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/ tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia.",

keywords = "Cognition, cognitive assessment, cognitive enhancement, neurocognition, psychopharmacology, schizophrenia",

author = "Green, {Michael F.} and Nuechterlein, {Keith H.} and Gold, {James M.} and Barch, {Deanna M.} and Cohen, {Jonathan D.} and Susan Essock and Fenton, {Wayne S.} and Fred Frese and Goldberg, {Terry E.} and Heaton, {Robert K.} and Keefe, {Richard S.E.} and Kern, {Robert S.} and Helena Kraemer and Ellen Stover and Weinberger, {Daniel R.} and Steven Zalcman and Marder, {Stephen R.}",

note = "Funding Information: The conference “Identifying Cognitive Targets and Establishing Criteria for Test Selection” was supported by MH22006 Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS; SRM, MFG). ",

year = "2004",

month = sep,

day = "1",

doi = "10.1016/j.biopsych.2004.06.023",

language = "English (US)",

volume = "56",

pages = "301--307",

journal = "Biological Psychiatry",

issn = "0006-3223",

publisher = "Elsevier Inc.",

number = "5",

}

Green, MF, Nuechterlein, KH, Gold, JM, Barch, DM, Cohen, JD, Essock, S, Fenton, WS, Frese, F, Goldberg, TE, Heaton, RK, Keefe, RSE, Kern, RS, Kraemer, H, Stover, E, Weinberger, DR, Zalcman, S & Marder, SR 2004, 'Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria', Biological Psychiatry, vol. 56, no. 5, pp. 301-307. https://doi.org/10.1016/j.biopsych.2004.06.023

TY - JOUR

T1 - Approaching a consensus cognitive battery for clinical trials in schizophrenia

T2 - The NIMH-MATRICS conference to select cognitive domains and test criteria

AU - Green, Michael F.

AU - Nuechterlein, Keith H.

AU - Gold, James M.

AU - Barch, Deanna M.

AU - Cohen, Jonathan D.

AU - Essock, Susan

AU - Fenton, Wayne S.

AU - Frese, Fred

AU - Goldberg, Terry E.

AU - Heaton, Robert K.

AU - Keefe, Richard S.E.

AU - Kern, Robert S.

AU - Kraemer, Helena

AU - Stover, Ellen

AU - Weinberger, Daniel R.

AU - Zalcman, Steven

AU - Marder, Stephen R.

N1 - Funding Information: The conference “Identifying Cognitive Targets and Establishing Criteria for Test Selection” was supported by MH22006 Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS; SRM, MFG).

PY - 2004/9/1

Y1 - 2004/9/1

N2 - To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) established the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference. The goals of the meeting were to 1) identify the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literature and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory, reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability, high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/ tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia.

AB - To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) established the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference. The goals of the meeting were to 1) identify the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literature and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory, reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability, high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/ tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia.

KW - Cognition

KW - cognitive assessment

KW - cognitive enhancement

KW - neurocognition

KW - psychopharmacology

KW - schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=4444220908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444220908&partnerID=8YFLogxK

U2 - 10.1016/j.biopsych.2004.06.023

DO - 10.1016/j.biopsych.2004.06.023

M3 - Review article

C2 - 15336511

AN - SCOPUS:4444220908

SN - 0006-3223

VL - 56

SP - 301

EP - 307

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 5

ER -

Approaching a consensus cognitive battery for clinical trials in schizophrenia: The NIMH-MATRICS conference to select cognitive domains and test criteria

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this