Approaches to organize cells on surfaces

J. L. Tan, C. M. Nelson, D. S. Gray, C. S. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The binding of cell surface receptors to local bioactive ligands is the principal mechanism by which cells survey their microenvironment and accordingly modulate their behaviors, such as proliferation, differentiation, migration, and suicide. Using microfabrication approaches to engineer cellular microenvironments, we examine how the spatial positioning of cells and their intercellular contacts can control cellular functions. Here, we describe methods to pattern the adhesivity of surfaces to 1) control the position of cells on surfaces, 2) measure forces generated by cells against deformable substrata, and 3) control the extent of cell-to-cell contact. We hope to use the microengineered substrates to improve the interface between artificial surfaces and living cells.

Original languageEnglish (US)
Title of host publication2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings
EditorsDavid Beebe, Andre Dittmar
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages101-103
Number of pages3
ISBN (Electronic)0780374800, 9780780374805
DOIs
StatePublished - Jan 1 2002
Externally publishedYes
Event2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Madison, United States
Duration: May 2 2002May 4 2002

Publication series

Name2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings

Other

Other2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology
CountryUnited States
CityMadison
Period5/2/025/4/02

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Microbiology (medical)

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  • Cite this

    Tan, J. L., Nelson, C. M., Gray, D. S., & Chen, C. S. (2002). Approaches to organize cells on surfaces. In D. Beebe, & A. Dittmar (Eds.), 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings (pp. 101-103). [1002273] (2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MMB.2002.1002273