Application of supercritical fluids for the production of sustained delivery devices

Pablo G. Debenedetti; Jean W. Tom; Yeo Sang-Do; Lim Gio-Bin

doi:10.1016/0168-3659(93)90166-3

Application of supercritical fluids for the production of sustained delivery devices

Pablo G. Debenedetti
, Jean W. Tom
, Yeo Sang-Do
, Lim Gio-Bin

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

Supercritical fluids are attractive as vehicles for the formation of particles of biomedical interest. We review two novel techniques: the rapid expansion of supercritical solutions for the formation of solvent-free, drug-loaded, injectable microspheres, and the gas anti-solvent precipitation process for the formation of ultrafine and biologically active protein powders.

Original language	English (US)
Pages (from-to)	27-44
Number of pages	18
Journal	Journal of Controlled Release
Volume	24
Issue number	1-3
DOIs	https://doi.org/10.1016/0168-3659(93)90166-3
State	Published - May 1 1993

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

Keywords

Anti-solvent precipitation
Rapid expansion
Supercritical fluid
Sustained delivery device

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10.1016/0168-3659(93)90166-3

Cite this

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title = "Application of supercritical fluids for the production of sustained delivery devices",

abstract = "Supercritical fluids are attractive as vehicles for the formation of particles of biomedical interest. We review two novel techniques: the rapid expansion of supercritical solutions for the formation of solvent-free, drug-loaded, injectable microspheres, and the gas anti-solvent precipitation process for the formation of ultrafine and biologically active protein powders.",

keywords = "Anti-solvent precipitation, Rapid expansion, Supercritical fluid, Sustained delivery device",

author = "Debenedetti, \{Pablo G.\} and Tom, \{Jean W.\} and Yeo Sang-Do and Lim Gio-Bin",

note = "Funding Information: PGD gratefully acknowledgest he support of Enzytech, Inc.; the National ScienceF oundation (Grant CTS-90006 14); the Camille and Henry Dreyfus Foundation ( 1989 Teacher-Scholar Award); the John Simon GuggenheimM emorial Foundation ( 199 1F ellowship); and thanksP ro-fessorJ ohn M. Prausnitz for his hospitality during a sabbatical leave at the Department of Chemical Engineeringa t the University of California at Berkeley. JWT is a National Science Foundation Pre-Doctoral Fellow. The lovastatin wasg enerouslyd onatedb y Merck ResearchL ab-oratories (Rahway, NJ).",

year = "1993",

month = may,

day = "1",

doi = "10.1016/0168-3659(93)90166-3",

language = "English (US)",

volume = "24",

pages = "27--44",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Application of supercritical fluids for the production of sustained delivery devices

AU - Debenedetti, Pablo G.

AU - Tom, Jean W.

AU - Sang-Do, Yeo

AU - Gio-Bin, Lim

N1 - Funding Information: PGD gratefully acknowledgest he support of Enzytech, Inc.; the National ScienceF oundation (Grant CTS-90006 14); the Camille and Henry Dreyfus Foundation ( 1989 Teacher-Scholar Award); the John Simon GuggenheimM emorial Foundation ( 199 1F ellowship); and thanksP ro-fessorJ ohn M. Prausnitz for his hospitality during a sabbatical leave at the Department of Chemical Engineeringa t the University of California at Berkeley. JWT is a National Science Foundation Pre-Doctoral Fellow. The lovastatin wasg enerouslyd onatedb y Merck ResearchL ab-oratories (Rahway, NJ).

PY - 1993/5/1

Y1 - 1993/5/1

N2 - Supercritical fluids are attractive as vehicles for the formation of particles of biomedical interest. We review two novel techniques: the rapid expansion of supercritical solutions for the formation of solvent-free, drug-loaded, injectable microspheres, and the gas anti-solvent precipitation process for the formation of ultrafine and biologically active protein powders.

AB - Supercritical fluids are attractive as vehicles for the formation of particles of biomedical interest. We review two novel techniques: the rapid expansion of supercritical solutions for the formation of solvent-free, drug-loaded, injectable microspheres, and the gas anti-solvent precipitation process for the formation of ultrafine and biologically active protein powders.

KW - Anti-solvent precipitation

KW - Rapid expansion

KW - Supercritical fluid

KW - Sustained delivery device

UR - https://www.scopus.com/pages/publications/0027213325

UR - https://www.scopus.com/pages/publications/0027213325#tab=citedBy

U2 - 10.1016/0168-3659(93)90166-3

DO - 10.1016/0168-3659(93)90166-3

M3 - Article

AN - SCOPUS:0027213325

SN - 0168-3659

VL - 24

SP - 27

EP - 44

JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 1-3

ER -

Application of supercritical fluids for the production of sustained delivery devices

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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