TY - JOUR
T1 - Application of supercritical fluids for the production of sustained delivery devices
AU - Debenedetti, Pablo G.
AU - Tom, Jean W.
AU - Sang-Do, Yeo
AU - Gio-Bin, Lim
N1 - Funding Information:
PGD gratefully acknowledgest he support of Enzytech, Inc.; the National ScienceF oundation (Grant CTS-90006 14); the Camille and Henry Dreyfus Foundation ( 1989 Teacher-Scholar Award); the John Simon GuggenheimM emorial Foundation ( 199 1F ellowship); and thanksP ro-fessorJ ohn M. Prausnitz for his hospitality during a sabbatical leave at the Department of Chemical Engineeringa t the University of California at Berkeley. JWT is a National Science Foundation Pre-Doctoral Fellow. The lovastatin wasg enerouslyd onatedb y Merck ResearchL ab-oratories (Rahway, NJ).
PY - 1993/5/1
Y1 - 1993/5/1
N2 - Supercritical fluids are attractive as vehicles for the formation of particles of biomedical interest. We review two novel techniques: the rapid expansion of supercritical solutions for the formation of solvent-free, drug-loaded, injectable microspheres, and the gas anti-solvent precipitation process for the formation of ultrafine and biologically active protein powders.
AB - Supercritical fluids are attractive as vehicles for the formation of particles of biomedical interest. We review two novel techniques: the rapid expansion of supercritical solutions for the formation of solvent-free, drug-loaded, injectable microspheres, and the gas anti-solvent precipitation process for the formation of ultrafine and biologically active protein powders.
KW - Anti-solvent precipitation
KW - Rapid expansion
KW - Supercritical fluid
KW - Sustained delivery device
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U2 - 10.1016/0168-3659(93)90166-3
DO - 10.1016/0168-3659(93)90166-3
M3 - Article
AN - SCOPUS:0027213325
VL - 24
SP - 27
EP - 44
JO - Journal of Controlled Release
JF - Journal of Controlled Release
SN - 0168-3659
IS - 1-3
ER -