Application of supercritical fluids for the production of sustained delivery devices

Pablo G. Debenedetti, Jean W. Tom, Yeo Sang-Do, Lim Gio-Bin

Research output: Contribution to journalArticle

139 Scopus citations

Abstract

Supercritical fluids are attractive as vehicles for the formation of particles of biomedical interest. We review two novel techniques: the rapid expansion of supercritical solutions for the formation of solvent-free, drug-loaded, injectable microspheres, and the gas anti-solvent precipitation process for the formation of ultrafine and biologically active protein powders.

Original languageEnglish (US)
Pages (from-to)27-44
Number of pages18
JournalJournal of Controlled Release
Volume24
Issue number1-3
DOIs
StatePublished - May 1 1993

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Anti-solvent precipitation
  • Rapid expansion
  • Supercritical fluid
  • Sustained delivery device

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