@article{e0e9d3fcd4ce4d68ab82f2a29a664582,
title = "Application of supercritical fluids for the production of sustained delivery devices",
abstract = "Supercritical fluids are attractive as vehicles for the formation of particles of biomedical interest. We review two novel techniques: the rapid expansion of supercritical solutions for the formation of solvent-free, drug-loaded, injectable microspheres, and the gas anti-solvent precipitation process for the formation of ultrafine and biologically active protein powders.",
keywords = "Anti-solvent precipitation, Rapid expansion, Supercritical fluid, Sustained delivery device",
author = "Debenedetti, {Pablo G.} and Tom, {Jean W.} and Yeo Sang-Do and Lim Gio-Bin",
note = "Funding Information: PGD gratefully acknowledgest he support of Enzytech, Inc.; the National ScienceF oundation (Grant CTS-90006 14); the Camille and Henry Dreyfus Foundation ( 1989 Teacher-Scholar Award); the John Simon GuggenheimM emorial Foundation ( 199 1F ellowship); and thanksP ro-fessorJ ohn M. Prausnitz for his hospitality during a sabbatical leave at the Department of Chemical Engineeringa t the University of California at Berkeley. JWT is a National Science Foundation Pre-Doctoral Fellow. The lovastatin wasg enerouslyd onatedb y Merck ResearchL ab-oratories (Rahway, NJ).",
year = "1993",
month = may,
day = "1",
doi = "10.1016/0168-3659(93)90166-3",
language = "English (US)",
volume = "24",
pages = "27--44",
journal = "Journal of Controlled Release",
issn = "0168-3659",
publisher = "Elsevier B.V.",
number = "1-3",
}