Abstract
Supercritical fluids are attractive as vehicles for the formation of particles of biomedical interest. We review two novel techniques: the rapid expansion of supercritical solutions for the formation of solvent-free, drug-loaded, injectable microspheres, and the gas anti-solvent precipitation process for the formation of ultrafine and biologically active protein powders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 27-44 |
| Number of pages | 18 |
| Journal | Journal of Controlled Release |
| Volume | 24 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - May 1 1993 |
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
Keywords
- Anti-solvent precipitation
- Rapid expansion
- Supercritical fluid
- Sustained delivery device
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Cite this
Debenedetti, P. G., Tom, J. W., Sang-Do, Y., & Gio-Bin, L. (1993). Application of supercritical fluids for the production of sustained delivery devices. Journal of Controlled Release, 24(1-3), 27-44. https://doi.org/10.1016/0168-3659(93)90166-3