Application of indane-derived C2-symmetric bis(oxazolines) in two-point binding asymmetric Diels-Alder reactions

Ian W. Davies, Chris H. Senanayake, Robert D. Larsen, Thomas R. Verhoeven, Paul J. Reider

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Abstract

Summary: Bis(oxazolines) 1 - 5 were examined in copper(II)-catalyzed asymmetric Diels-Alder reactions of acrylimide 6 and cyclopentadiene. Highly enantioselective reactions were attained with ligand 1 (up to 95% e.e.) as well as good endo selectivity (39:1) in the Cu(SbF6)2-catalyzed process.

Original languageEnglish (US)
Pages (from-to)1725-1726
Number of pages2
JournalTetrahedron Letters
Volume37
Issue number11
DOIs
StatePublished - Mar 11 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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