Anti-Markovnikov Hydrofunctionalization of Olefins Mediated by Rhodium-Porphyrin Complexes

Melanie S. Sanford, John Taylor Groves

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

A rationally designed mechanistic approach to anti-Markovnikov olefin hydrofunctionalization and its application to the synthesis of heterocycles are described. Porphyrin-rhodium complexes have been shown to exhibit remarkable reactivity and selectivity for each step of the proposed catalytic cycle (see scheme). A critical step of this reaction sequence is a new, facile, and remarkably general carbon-heteroatom bond-forming reductive elimination.

Original languageEnglish (US)
Pages (from-to)588-590
Number of pages3
JournalAngewandte Chemie - International Edition
Volume43
Issue number5
DOIs
StatePublished - Jan 23 2004

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Keywords

  • Alkenes
  • Hydroamination
  • Porphyrinoids
  • Reductive elimination
  • Rhodium

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