An interrupted Ugi reaction enables the preparation of substituted indoxyls and aminoindoles

John S. Schneekloth, Jr ,.Jimin Kim, Erik J. Sorensen

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

In a variation of the classical Ugi reaction, an acid-promoted reaction between imines and isocyanides forms both 3-aminoindoles and substituted indoxyls. A recently reported triflyl phosphoramide is shown to be critical to obtain high yields under mild conditions.

Original languageEnglish (US)
Pages (from-to)3096-3101
Number of pages6
JournalTetrahedron
Volume65
Issue number16
DOIs
StatePublished - Apr 18 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Keywords

  • Heterocycles
  • Isocyanides
  • Multicomponent reactions
  • Synthetic methods

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