An expedient synthesis of maraviroc (UK-427,857) via C-H functionalization

T. Aaron Bedell, Graham A.B. Hone, Justin Du Bois, Erik J. Sorensen

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Abstract A new, concise synthesis of the CCR-5 receptor antagonist maraviroc (UK-427,857) from 3-phenyl-1-propanol has been completed in four steps featuring a site-selective C-H functionalization.

Original languageEnglish (US)
Article number45744
Pages (from-to)3620-3623
Number of pages4
JournalTetrahedron Letters
Volume56
Issue number23
DOIs
StatePublished - May 25 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Keywords

  • Amination
  • C-H functionalization
  • CCR-5
  • HIV/AIDS
  • Maraviroc

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