An expedient synthesis of maraviroc (UK-427,857) via C-H functionalization

T. Aaron Bedell; Graham A.B. Hone; Justin Du Bois; Erik J. Sorensen

doi:10.1016/j.tetlet.2015.01.074

An expedient synthesis of maraviroc (UK-427,857) via C-H functionalization

T. Aaron Bedell, Graham A.B. Hone, Justin Du Bois, Erik J. Sorensen

Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Abstract A new, concise synthesis of the CCR-5 receptor antagonist maraviroc (UK-427,857) from 3-phenyl-1-propanol has been completed in four steps featuring a site-selective C-H functionalization.

Original language	English (US)
Article number	45744
Pages (from-to)	3620-3623
Number of pages	4
Journal	Tetrahedron Letters
Volume	56
Issue number	23
DOIs	https://doi.org/10.1016/j.tetlet.2015.01.074
State	Published - May 25 2015

All Science Journal Classification (ASJC) codes

Drug Discovery
Biochemistry
Organic Chemistry

Keywords

Amination
C-H functionalization
CCR-5
HIV/AIDS
Maraviroc

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10.1016/j.tetlet.2015.01.074

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title = "An expedient synthesis of maraviroc (UK-427,857) via C-H functionalization",

abstract = "Abstract A new, concise synthesis of the CCR-5 receptor antagonist maraviroc (UK-427,857) from 3-phenyl-1-propanol has been completed in four steps featuring a site-selective C-H functionalization.",

keywords = "Amination, C-H functionalization, CCR-5, HIV/AIDS, Maraviroc",

author = "Bedell, {T. Aaron} and Hone, {Graham A.B.} and {Du Bois}, Justin and Sorensen, {Erik J.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = may,

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doi = "10.1016/j.tetlet.2015.01.074",

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T1 - An expedient synthesis of maraviroc (UK-427,857) via C-H functionalization

AU - Bedell, T. Aaron

AU - Hone, Graham A.B.

AU - Du Bois, Justin

AU - Sorensen, Erik J.

PY - 2015/5/25

Y1 - 2015/5/25

N2 - Abstract A new, concise synthesis of the CCR-5 receptor antagonist maraviroc (UK-427,857) from 3-phenyl-1-propanol has been completed in four steps featuring a site-selective C-H functionalization.

AB - Abstract A new, concise synthesis of the CCR-5 receptor antagonist maraviroc (UK-427,857) from 3-phenyl-1-propanol has been completed in four steps featuring a site-selective C-H functionalization.

KW - Amination

KW - C-H functionalization

KW - CCR-5

KW - HIV/AIDS

KW - Maraviroc

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M3 - Article

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ER -

An expedient synthesis of maraviroc (UK-427,857) via C-H functionalization

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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